Renato A Polimanti

This paper conducts a large-scale epigenome-wide association study of PTSD in the Million Veteran Program, identifying 272 CpG sites associated with PTSD traits and replicating prior findings.

The paper identifies a mid-gestational molecular mechanism linking cortical size and ADHD through genetic and single-cell RNA sequencing analyses.

This study identifies shared genetic and neurobiological pathways between problematic alcohol use and anxiety disorders using genomic analyses.

The paper identifies shared epigenetic and genetic loci between generalized anxiety disorder and COVID-19, implicating neuroimmune pathways in their comorbidity.

This study identifies shared and disorder-specific genetic loci across internalizing disorders using a multivariate genome-wide association approach in diverse populations.

This study identifies genetic correlations and pleiotropy between neurodevelopmental disorders and hearing problems, suggesting shared biological mechanisms.

This paper identifies 90 genome-wide significant SNPs for suicidal behaviors in diverse populations, with 49 novel findings, and highlights genetic correlations with mental and physical health traits.

This study links COVID-19 outcomes to brain structure and function through genetic correlations and identifies potential drug targets.

This study identifies shared genetic factors between insomnia, depression, and anxiety, highlighting synaptic processes as potential drug targets.

This study identifies 80 genome-wide significant associations for endometriosis and adenomyosis in 1.4 million women, uncovering novel loci and pathways involved in disease mechanisms.

This study identifies 1,257 genetic variants associated with human personality traits using large-scale GWAS and finds widespread genetic correlations with behaviors and life outcomes.

This study performs a multi-ancestral GWAS of DSM-defined nicotine dependence, finding genetic correlations with other substance use disorders and health traits, and identifying a strong general addiction liability factor.

This study identifies shared genetic loci and genes between PTSD and cardiovascular conditions using GWAS across multiple data sources and finds overlapping biological pathways and drug targets.

Population-stratified GWAS of 2,068 traits in 635,969 Million Veteran Program participants, 29% genetically non-European, yields 98,485 associations and 57,601 fine-mapped signals with largely shared cross-population architecture.

This study investigates sex differences in the genetic pleiotropy between hearing difficulty and brain imaging-derived phenotypes using large-scale GWAS data and multiple analytical methods.

This study identifies 16 tandem repeats associated with hair color across multiple ancestries and shows they can predict hair color independently of SNPs.

This study identifies 51 anxiety-associated genetic loci from a multi-ancestry GWAS of 1.2 million participants and highlights genetic correlations with other mental and physical health conditions.

The paper identifies exome-wide tandem repeats associated with subcortical volumes and psychiatric symptoms in UK Biobank participants.

The paper investigates the genetic correlation between schizophrenia and household income, finding no significant effect of socioeconomic status on schizophrenia's pleiotropy with health outcomes.

This study investigates genetic correlations between COVID-19 outcomes and anxiety disorders/symptoms using large-scale genomic datasets, finding bidirectional genetic causality and shared loci related to lung function and brain morphology.

The paper analyzes polygenicity differences across health domains in East Asian and European populations using genome-wide data from multiple cohorts.

The paper analyzes autozygosity trends across three large cohorts, finding a decline over time with country-specific variations and potential socioeconomic factors influencing the trend.

This study identifies 46 genetically correlated traits with ALS using GWAS data and performs causal inference, finding bidirectional genetic effects on several traits.

The paper compares two measures of suicidality using genome-wide data, finding that an aggregate phenotype has higher heritability and better predictive power than a genetically derived S-factor.

The paper identifies de novo tandem repeat mutations in UK Biobank exomes and associates them with various phenotypes, finding significant links to health and disease outcomes.

The paper examines how assortative mating, participation bias, and socioeconomic status affect polygenic risk scores for behavioral and psychiatric traits using genetic and demographic data.

The paper tests if self-domestication and neural crest loci contribute to neurodevelopmental disorder heritability, finding significant enrichments that disappear when other genomic annotations are included.

This paper identifies genetic loci associated with short and long sleep duration through a cross-population meta-analysis and explores their genetic correlations and causal relationships with depression.

This study investigates the genetic and longitudinal relationship between posttraumatic stress disorder and coronary artery disease using genome-wide data and electronic health records.