Frank R. Wendt

Investigating shared genetic architecture between pigmentation genetics and Parkinson's Disease

The paper examines genetic links between pigmentation traits and Parkinson's Disease using LDSC, PRS, MR, and multi-trait analysis, finding limited shared variation and no causal relationships.

Multi-ancestry tandem repeat association study of hair color using exome-wide sequencing

This study identifies 16 tandem repeats associated with hair color across multiple ancestries and shows they can predict hair color independently of SNPs.

Exome-wide tandem repeats confer large effects on subcortical volumes in UK Biobank participants

The paper identifies exome-wide tandem repeats associated with subcortical volumes and psychiatric symptoms in UK Biobank participants.

Characterizing the polygenic architecture of complex traits in populations of East Asian and European descent

The paper analyzes polygenicity differences across health domains in East Asian and European populations using genome-wide data from multiple cohorts.

Declining autozygosity over time: an exploration in over 1 million individuals from three diverse cohorts

The paper analyzes autozygosity trends across three large cohorts, finding a decline over time with country-specific variations and potential socioeconomic factors influencing the trend.

Functional and molecular characterization of suicidality factors using phenotypic and genome-wide data

The paper compares two measures of suicidality using genome-wide data, finding that an aggregate phenotype has higher heritability and better predictive power than a genetically derived S-factor.

Phenome-wide association study of loci harboring de novo tandem repeat mutations in UK Biobank exomes

The paper identifies de novo tandem repeat mutations in UK Biobank exomes and associates them with various phenotypes, finding significant links to health and disease outcomes.

The impact of assortative mating, participation bias, and socioeconomic status on the polygenic risk of behavioral and psychiatric traits

The paper examines how assortative mating, participation bias, and socioeconomic status affect polygenic risk scores for behavioral and psychiatric traits using genetic and demographic data.

Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records

This study investigates the genetic and longitudinal relationship between posttraumatic stress disorder and coronary artery disease using genome-wide data and electronic health records.

Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors

This paper conducts a multi-ancestry GWAS meta-analysis of suicide attempt, identifying 12 genome-wide significant loci and finding shared genetic risks with ADHD, smoking, and risk tolerance.

Genome-wide investigation of maximum habitual alcohol intake (MaxAlc) in 247,755 European and African Ancestry U.S. Veterans informs the relationship between habitual alcohol consumption and alcohol use disorder.

This paper identifies 15 genome-wide significant loci for maximum habitual alcohol intake (MaxAlc) in 247,755 U.S. Veterans and shows strong genetic correlations with alcohol use disorder and psychiatric traits.

Sex differences, cross-ancestry generalizability, and noise-smoking interactions in the polygenic architecture of hearing loss in adults

This study identifies 54 risk loci for hearing loss in adults across multiple cohorts, revealing sex differences, ancestry-specific polygenic risks, and interactions with environmental factors like noise and smoking.

Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program

This study analyzes ancestry diversity changes in the Million Veteran Program over time and shows that refined ancestry modeling reduces population stratification in GWAS of height.

The integration of genetically-regulated transcriptomics and electronic health records highlights a pattern of medical outcomes related to increased hepatic Transthyretin expression

This paper integrates genetic transcriptomics and electronic health records to show increased hepatic Transthyretin expression is linked to specific surgical procedures and health outcomes like osteoarthritis and carpal tunnel syndrome.

Host genetic liability for severe COVID-19 overlaps with alcohol drinking behavior and diabetic outcomes in over 1 million participants

The paper investigates genetic correlations between severe COVID-19 and traits like alcohol use and diabetes in over 1 million participants, showing genetic links and potential causality.

Drinking and smoking polygenic risk is associated with neurodevelopmental outcomes of children and young adults independently of psychopathology and substance use.

The paper investigates the association between polygenic risk scores for drinking and smoking behaviors and neurodevelopmental outcomes in children and young adults, finding independent effects from psychopathology and substance use.

ACE2 Netlas: In-silico functional characterization and drug-gene interactions of ACE2 gene network to understand its potential involvement in COVID-19 susceptibility

The paper functionally characterizes the ACE2 gene network to identify potential mechanisms of COVID-19 susceptibility and drug-gene interactions.

The impact of evolutionary processes in shaping the genetics of complex traits in East Asia and Europe: a specific contribution from Denisovan and Neanderthal introgression

The paper investigates how evolutionary processes, including Denisovan and Neanderthal introgression, affect the genetics of complex traits in East Asians using genome-wide association data.

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

This study identifies genetic variants shared between schizophrenia and alcohol use disorder, finding both convergent and divergent effects and evidence of brain tissue expression.

GWAS of Depression Phenotypes in the Million Veteran Program and Meta-analysis in More than 1.2 Million Participants Yields 178 Independent Risk Loci

This study identifies 178 independent risk loci for depression through a large meta-analysis across multiple cohorts, including fine-mapping and transcriptome-wide association findings.

Biobank scale pharmacogenomics informs the genetic underpinnings of simvastatin use

This paper identifies associations between NAT2 haplotype variation and simvastatin use, showing NAT2*1 is linked to better response to simvastatin therapy.

Shared loci of telomere length with brain morphology, and pleiotropy in transcriptomic and epigenomic profiles of brain

The paper identifies shared genetic loci between telomere length and brain morphology, and finds regulatory gene associations in brain transcriptomic and epigenomic profiles.

Epigenomic profiles of African American Transthyretin Val122Ile carriers reveals putatively dysregulated amyloid mechanisms

This study identifies epigenomic changes in African American Transthyretin Val122Ile carriers linked to heart disease and outpatient surgeries, revealing dysregulated amyloid mechanisms.

Mapping the human genetic architecture of COVID-19 by worldwide meta-analysis

This study identifies 13 genome-wide significant loci associated with SARS-CoV-2 infection or severe COVID-19 through a global meta-analysis of 49,562 patients.

Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization

Genome-wide association study and integrative analyses identify 27 genes in inflammation and coagulation pathways linked to COVID-19 hospitalization risk and symptomology.

Complex multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidal behaviors

The paper investigates gene-environment interactions between polysubstance dependence and suicidal behaviors using two cohorts, finding significant associations and gene clusters linked to these interactions.

Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample

This study identifies genetic loci associated with PTSD and its symptoms using a large veteran cohort, showing high genetic correlations between symptom sub-domains and potential drug targets.

Metabolome-Wide Mendelian Randomization Analysis of Emotional and Behavioral Responses to Traumatic Stress

This study uses metabolome-wide Mendelian randomization to identify causal relationships between blood metabolites and trauma response traits in the UK Biobank.

DRD2 and FOXP2 are implicated in the associations between computerized device use and psychiatric disorders

The paper investigates genetic overlaps between computerized device use and psychiatric disorders, identifying shared molecular pathways involving DRD2 and FOXP2.