Identification and verification of the potential effect of therapeutic miRNA-mRNA pairs on ferroptosis in small cell lung cancer by bioinformatics analysis

Abstract

Owing to the high mortality rate of small cell lung cancer (SCLC), it is essential to determine a novel therapeutic approach for treating patients with SCLC. miRNA is a type of non-coding RNA that plays a role in translational control. By applying this identity, it is applicable for treating patients using miRNA and nanotechnology. Ferroptosis is a newly discovered type of programmed cell death. Accumulated evidence suggests the possibility of using ferroptosis in treating patients with SCLC. Thus, identifying potential therapeutic miRNA-mRNA pairs that have an impact on ferroptosis will be valuable. In the in silico analysis, several Gene Expression Omnibus datasets were analyzed. The results were verified using other data. Here, we report that the miR-30 family and KIF11 pair have a crucial influence on SCLC cells, which may also affect ferroptosis.