Kamyar Hadian

Oxysterol-sensing by Liver X receptor counteracts ferroptosis via lipid remodeling

This study identifies LXR as an oxysterol-sensing suppressor of ferroptosis by promoting lipid remodeling that reduces lipid peroxidation.

miR-940 suppresses ferroptosis by controlling expression of key regulatory genes

This study identifies miR-940 as a negative regulator of ferroptosis, showing it suppresses cell death by modulating key genes and GPX4 levels in cancer cells.

In vitro model of human subcutaneous adipocyte spheroids for studying mitochondrial dysfunction and mitochondria activating compounds

The paper develops an in vitro model of human subcutaneous adipocyte spheroids to study mitochondrial dysfunction and test mitochondria-activating compounds in obesity.

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance

This study identifies riboflavin as a modulator of ferroptosis sensitivity by supporting FSP1 stability and antioxidant recycling, with implications for therapeutic targeting.

Scalable and universal prediction of cellular phenotypes enables in silico experiments

Prophet predicts cellular phenotypes from perturbations using transfer learning, outperforming baselines and enabling in silico screening for therapeutic discovery.