Oxysterol-sensing by Liver X receptor counteracts ferroptosis via lipid remodeling
Andrea Kolak, Juliane Tschuck, Shibo Sun, Judith Sailer, Oliver Hartmann, Ina Rothenaigner, Huiyun Hu, Elizaveta Efanova, Fabien Riols, Mark Haid, Hans Zischka, Markus E. Diefenbacher, José Pedro Friedmann Angeli, Kamyar Hadian
This study identifies LXR as an oxysterol-sensing suppressor of ferroptosis by promoting lipid remodeling that reduces lipid peroxidation.
bioRxiv · Aug 20, 2026 · PreprintCell Biology