From concept to clinic: mathematically informed immunotherapy

Abstract

Introduction Introduction Mathematical oncology Immunotherapy Modeling tumor-immune... Modeling treatment outcomes Adoptive T-cell and cytokine... Dendritic cell vaccines Preventative vaccines Cancer-specific treatments Combination therapies Discussion Summary References Mathematical modeling has become a valuable tool in the continued effort to understand, predict and ultimately treat a wide range of cancers in recent years [1,2]. By describing biological phenomena in the concise and formal language of mathematics, it is possible to elucidate key components of complex systems and ultimately develop tools capable of quantifying and ...