Alexander RA Anderson

Estimating stem cell fractions in hierarchically organized tumors

The paper develops a mathematical model to estimate cancer stem cell fractions in tumors using tumor size measurements and linear regression, without requiring detailed microscopic data.

Stochasticity in the Genotype-Phenotype Map: Implications for the Robustness and Persistence of Bet-Hedging

This paper explores the genotype-phenotype map using molecular switches to show how robustness and persistence emerge, explaining bet-hedging strategies and their implications for treatment resistance.

Spatial metrics of tumour vascular organisation predict radiation efficacy in a computational model

This paper uses a computational model to show that spatial organization of blood vessels in tumors affects radiation response, with varying correlations depending on vessel density.

Exploiting evolutionary non-commutativity to prevent the emergence of bacterial antibiotic resistance

This paper develops a Markov Chain model to analyze antibiotic resistance emergence in E. coli and shows that drug sequencing can probabilistically steer populations away from resistance.