Tyler Cassidy

This study develops a mathematical model to simulate retinal microglia migration during inflammation, showing that LPS delivery route and species-specific pharmacokinetics drive redistribution patterns.

The paper develops a model to show phenotypic adaptation drives drug resistance in BRAFV600E-mutant melanoma and suggests intermittent treatments may be more effective.

This paper develops a stochastic model to assess the identifiability of phenotypic adaptation parameters from low-cell-count experiments and shows that cell-to-cell heterogeneity is non-identifiable from population-level data.

The paper develops a multiscale model of CAM treatment in chronic HBV infection, showing HBV RNA is more sensitive to CAM effectiveness than HBV DNA.

This paper uses mathematical modeling to analyze the relationship between monocyte and neutrophil levels during chemotherapy and shows that monocytopenia precedes neutropenia, informing G-CSF dosing strategies.

This paper develops a mathematical model of tumour-immune interaction with distributed delays to study the impact of tumour-immune dynamics on disease progression and response to viral therapy.