UT-018, A Stem-Cell Chemoattractant Nutraceutical for intestinal Healing in DSS-Induced Colitis

Abstract

We show here that UT-018, a proprietary nutraceutical designed to act as a stem-cell chemoattractant, protects against DSS-induced colitis in mice. UT-018 composed of amino acids and organic acid, promotes epithelial repair and mucosal regeneration by enhancing endogenous stem-cell migration and modulating inflammation. Treatment resulted in rapid recovery of body weight, reduced disease activity, and histological preservation of colonic mucosa. The effect was comparable to direct stem-cell delivery models reported elsewhere, achieved here through a safe, orally available formulation. UT-018 thus represents a new class of regenerative nutraceuticals that link metabolic signaling to mucosal healing.