Frank Pajonk

This study shows that exosomes mediate bidirectional signaling between glioma stem cells and non-stem cells, influencing their homeostasis and radiation-induced plasticity.

This paper evaluates the compound MXC-017 in treating DSS-induced colitis and radiation enteropathy in mice, showing reduced inflammation and improved intestinal function.

This study uses human cortical organoids to model radiation-induced neural injury and test mitigators, showing partial recovery and transcriptional changes with potential therapeutic interventions.

This study evaluates quetiapine as an adjuvant therapy for triple-negative breast cancer, showing it reduces clonogenicity, promotes apoptosis, and impairs DNA repair and migration.

This study examines transcriptomic changes in the murine duodenum after lethal total body irradiation and NSPP treatment, identifying regenerative gene activation during recovery.

This study identifies selumetinib as a compound that prevents radiation-induced conversion of non-tumor-initiating cells to glioma-initiating cells in glioblastoma.

The paper develops a novel urea-based compound, MXC-017, that crosses the blood-brain barrier, targets glioma stem cells, and improves survival in GBM models when combined with radiation.

This study shows that combining quetiapine and radiation therapy reduces mesothelioma-initiating cells and improves survival in a mouse model of mesothelioma.

This study shows that combining radiation with forskolin induces a differentiation-like state in glioma cells, reducing proliferation and extending survival in mouse models.

This study investigates how DAMPs influence radiation-induced plasticity in glioma-initiating cells through innate immune signaling pathways.

This study shows that activation of the mevalonate pathway and Rac-1 in glioblastoma cells after anti-cancer treatments promotes recurrence, and statins combined with radiation improve survival in mouse models.

This study shows dopamine receptor antagonists have sex-dependent effects on neural stem/progenitor cells, potentially reducing radiation-induced cognitive decline in glioblastoma treatment.

This paper shows that combining ONC201 with radiation improves GBM treatment efficacy by targeting glioma-initiating cells in vitro and in vivo without increased toxicity.

This study shows that combining quetiapine, atorvastatin, and radiation extends survival in glioblastoma mouse models by exploiting a metabolic vulnerability.

This paper shows that Compound #5 reduces radiation-induced cognitive decline in mice without affecting tumor growth.