Ling He

A novel vimentin-stabilizing urea compound MXC-017 ameliorates DSS-induced colitis and radiation enteropathy in mice

This paper evaluates the compound MXC-017 in treating DSS-induced colitis and radiation enteropathy in mice, showing reduced inflammation and improved intestinal function.

Temporal Mapping of Radiation-Induced Neural Injury and Mitigation in Human Cortical Organoids

This study uses human cortical organoids to model radiation-induced neural injury and test mitigators, showing partial recovery and transcriptional changes with potential therapeutic interventions.

Repurposing Quetiapine as an Adjuvant Therapeutic Agent for Triple-Negative Breast Cancer

This study evaluates quetiapine as an adjuvant therapy for triple-negative breast cancer, showing it reduces clonogenicity, promotes apoptosis, and impairs DNA repair and migration.

Bacillus velezensis GFZF-23 Alleviates Colitis through Microbiome Restoration and β-Sitosterol-Mediated Metabolic Reprogramming

This paper identifies Bacillus velezensis GFZF-23 as a probiotic that alleviates colitis by restoring the microbiome and reprogramming host metabolism through β-sitosterol.

Transcriptome of the murine duodenum during recovery after a lethal dose of total body irradiation

This study examines transcriptomic changes in the murine duodenum after lethal total body irradiation and NSPP treatment, identifying regenerative gene activation during recovery.

Combined quetiapine and radiation therapy approach to treat mesothelioma-initiating cells and increase survival in a mouse model of mesothelioma

This study shows that combining quetiapine and radiation therapy reduces mesothelioma-initiating cells and improves survival in a mouse model of mesothelioma.

Radiation-Induced Cellular Plasticity: A Strategy for Combatting Glioblastoma

This study shows that combining radiation with forskolin induces a differentiation-like state in glioma cells, reducing proliferation and extending survival in mouse models.

Targeting Innate Immune Signaling in Glioma-Initiating Cells Impairs Self-Renewal and Radiation-Induced Cellular Plasticity

This study investigates how DAMPs influence radiation-induced plasticity in glioma-initiating cells through innate immune signaling pathways.

Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1

This study shows that activation of the mevalonate pathway and Rac-1 in glioblastoma cells after anti-cancer treatments promotes recurrence, and statins combined with radiation improve survival in mouse models.

Effects of Dopamine Receptor Antagonists and Radiation on Mouse Neural Stem/Progenitor Cells

This study shows dopamine receptor antagonists have sex-dependent effects on neural stem/progenitor cells, potentially reducing radiation-induced cognitive decline in glioblastoma treatment.

Synergistic Effects of the DRD2/3 Antagonist ONC201 and Radiation in Glioblastoma

This paper shows that combining ONC201 with radiation improves GBM treatment efficacy by targeting glioma-initiating cells in vitro and in vivo without increased toxicity.

Combined Treatment with Dopamine Receptor Antagonists and Radiation Creates a Metabolic Vulnerability in Mouse Models of Glioblastoma

This study shows that combining quetiapine, atorvastatin, and radiation extends survival in glioblastoma mouse models by exploiting a metabolic vulnerability.

The Dopamine Receptor Antagonist TFP Prevents Phenotype Conversion and Improves Survival in Mouse Models of Glioblastoma

1--4-phenylpiperazine Treatment After Brain Irradiation Preserves Cognitive Function in Mice

This paper shows that Compound #5 reduces radiation-induced cognitive decline in mice without affecting tumor growth.