BMC BioinformaticsBioinformaticsPeer-reviewed journal article
nQuire: A Statistical Framework For Ploidy Estimation Using Next Generation Sequencing
Clemens L. WeißiD, Marina PaisiD, Liliana M. CanoiD, Sophien KamouniD, Hernán A. BurbanoiD
Abstract
SummarynQuire is a statistical framework that distinguishes between diploids, triploids and tetraploids using next generation sequencing. The command-line tool models the distribution of base frequencies at variable sites using a Gaussian Mixture Model, and uses maximum likelihood to select the most plausible ploidy model.\n\nAvailability and ImplementationThe model is implemented as a stand-alone Linux command line tool in the C programming language and is available at github under the MIT licence. Please also refer to github.com/clwgg/nQuire for usage instructions. Contact: clemens.weiss@tuebingen.mpg.de or hernan.burbano@tuebingen.mpg.de
- Citations
- 191
- FWCI
- 4.18
- Field percentile
- top 4%
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