Sophien Kamoun

This study identifies tissue-specific NLR expression patterns across legume species using phylogenomics and transcriptomics.

This study shows how a plant pathogen effector blocks the stepwise assembly of a helper NLR resistosome by stabilizing an intermediate state.

The paper identifies conserved sensor-helper NLR interfaces in the NRC immune receptor network and validates their role in immune activation through structural and functional studies.

The paper introduces SNI, a framework to identify atypical protein assemblies, and applies it to NLRs, finding an undecameric assembly in NRC7 orthologs.

This study identifies NRG1 as a plant NLR receptor that targets chloroplasts to trigger immunity by channeling stromal calcium into the cytosol, revealing a novel mechanism for organelle-specific immune signaling.

Activated wheat CCG10-NLR immune receptor WAI3 and Arabidopsis RPS2 assemble into octameric calcium-permeable resistosomes with an inverted coiled-coil domain topology associated with lacking the conserved EDVID motif.

This study determines the structural basis of broad recognition by the Arabidopsis NLR WRR4A, revealing a shape-based mechanism that enables recognition of diverse effectors with similar three-dimensional architectures.

The paper develops and characterizes three new polycistronic constructs for producing yellow and fluorescent betaxanthins in plants.

The paper investigates the evolution of APikL virulence effectors in the blast fungus by combining ancestral reconstruction and functional assays, finding that only one substitution expanded host binding while others were deleterious.

The paper shows that the rice NLR pair Pik-1 and Pik-2 forms a hetero-oligomeric complex at the plasma membrane in the resting state before effector activation.

The study shows that autoactive mutants of tomato NRC proteins still induce cell death in prf mutants and in lettuce, indicating a unidirectional dependency in the NRC immune network.

AlphaFold 3 oligomer models separate paired plant NLRs: helpers score higher pTM and form funnel-shaped resistosomes unlike sensors, including some rice pairs lacking integrated-domain annotations.

This paper identifies an effector from Phytophthora infestans that bridges NbTOL9a to an activated NLR to suppress immunity, revealing a novel structural and functional mechanism.

The paper shows that NRC3 evolved to resist suppression by a nematode effector, revealing a new type of gene-for-gene interaction between pathogens and host immune receptors.

The paper analyzes NLR evolution in lettuce and related species, finding that sensor NLRs evolve faster than helper NLRs and that sensor diversification is linked to helper dependency.

This study determines the structure of sensor-activated NbNRC2 using cryo-EM, revealing a hexameric resistosome and highlighting structural changes during NLR activation.

The paper shows that the rice NLR-ID receptor Pii2 indirectly recognizes the fungal effector AVR-Pii by dissociating Pii2 from host Exo70 proteins, revealing a novel mechanism of pathogen recognition.

The paper identifies horizontal mini-chromosome transfers in clonal blast fungus lineages, showing genetic exchange between host-associated isolates.

This study bioengineers proteases to convert Rcr3 orthologs and Pip1 into immune co-receptors that trigger Avr2/Cf-2 dependent immunity in tomato.

This study reports the diploid genome of the free-living diatom Nitzschia putrida and identifies genetic changes associated with its transition from a photosynthetic to a non-parasitic secondary heterotrophic lifestyle.

This study evaluates how SNP calling parameters affect population genetic analyses in the rice blast fungus, finding minimal impact on key evolutionary inferences despite variations in SNP counts.

The paper identifies and analyzes hypervariable mini-chromosomes in Magnaporthe oryzae isolates from different grass hosts, showing their role in genomic rearrangements and potential adaptive evolution.

This paper shows how a parasite effector protein manipulates host developmental processes by hijacking a ubiquitin receptor to induce phenotypic changes.

This study identifies 6mA methylation in Phytophthora genomes, showing its association with gene-sparse regions and adaptive evolution.

nQuire estimates ploidy (diploid, triploid, tetraploid) using NGS data with a Gaussian Mixture Model and maximum likelihood.

The paper shows that during P. infestans infection, ATG8CL autophagosomes are diverted to the pathogen interface, suggesting the pathogen coopts host selective autophagy.

The paper shows that Phytophthora infestans can infect Arabidopsis thaliana after being pre-infected with Albugo laibachii, with similar gene expression and haustoria formation to potato infections.

The paper identifies a South American lineage of Magnaporthe oryzae as the cause of a wheat blast outbreak in Bangladesh using transcriptome sequencing and population genomics.

The paper evaluates the cell re-entry assay for detecting effector protein uptake into plant cells and finds it unreliable due to false positives.

The study identifies NRC3 as required for Pto-mediated cell death in N. benthamiana, while NRC1 is not, using genome annotation, phylogenetics, and genetic experiments.