Gustavo Henrique Goldman

Opportunistic pathogenicity in fungi can transcend species boundaries

This study compares phenotypic, metabolomic, and genomic variation between two Aspergillus species to determine factors distinguishing opportunistic pathogens from non-pathogens.

Enhanced antifungal activity of NK-92 cells against Candida albicans mediated by a mannan-specific chimeric antigen receptor

This paper develops and tests CAR-NK-92 cells targeting Candida albicans mannan, showing enhanced antifungal activity and reduced fungal burden in mice.

RAB5c controls the assembly of non-canonical autophagy machinery to promote phagosome maturation and microbicidal function of macrophages

This study identifies RAB5c's role in regulating non-canonical autophagy machinery to enhance phagosome maturation and microbial killing by macrophages.

A novel Mannan-specific chimeric antigen receptor M-CAR redirects T cells to interact with Candida spp. hyphae and Rhizopus oryzae spores

This paper develops a Mannan-specific chimeric antigen receptor (M-CAR) that activates T cells against Candida spp. and Rhizopus oryzae, enhancing immune response against fungal infections.

Population genomics of Macrophomina spp. reveals cryptic host specialization and evidence for meiotic recombination

The paper uses population genomics to analyze Macrophomina spp. isolates, revealing host specialization and meiotic recombination.

Strain heterogeneity in a non-pathogenic fungus highlights factors contributing to virulence

This study examines strain variation in a non-pathogenic fungus, identifying factors linked to virulence differences across strains.

Milteforan, a promising veterinary commercial product against feline sporotrichosis

The paper shows milteforan, a veterinary product containing miltefosine, is effective against sporotrichosis caused by S. brasiliensis and S. schenckii in vitro and in infected cells.

Brilacidin, a host defense peptide mimetic, potentiates ibrexafungerp antifungal activity against the human pathogenic fungus Aspergillus fumigatus

This study shows that brilacidin enhances ibrexafungerp's antifungal effect against Aspergillus fumigatus, including strains resistant to caspofungin.

Brilacidin, a novel antifungal agent against Cryptococcus neoformans

This paper identifies brilacidin as a novel antifungal agent effective against Cryptococcus neoformans, showing it reduces fungal survival in macrophages and potentiates existing antifungals.

Whole-Genome Sequencing and Comparative Genomic Analysis of Potential Biotechnological Strains of Trichoderma harzianum, Trichoderma atroviride, and Trichoderma reesei

The paper performs whole-genome sequencing and comparative genomic analysis of Trichoderma strains to assess genetic diversity and identify structural variants.

Examination of genome-wide ortholog variation in clinical and environmental isolates of the fungal pathogen Aspergillus fumigatus

The paper examines genome-wide ortholog variation in 206 A. fumigatus isolates, finding no significant differences in ortholog distribution between clinical and environmental isolates after accounting for phylogeny.

Chromatin profiling reveals genome stability heterogeneity in clinical isolates of the human pathogen Aspergillus fumigatus

The paper compares chromatin activities in two A. fumigatus isolates, finding higher genome instability in Af293 and identifying a variant with chromosomal alterations linked to increased virulence.

POPULATION GENOMIC ANALYSIS OF CRYPTOCOCCUS BRAZILIAN ISOLATES REVEALS AN AFRICAN TYPE SUBCLADE DISTRIBUTION

This study analyzes the genomic structure of Brazilian Cryptococcus isolates, revealing an African-like subclade distribution and identifying a mutator phenotype in one isolate.

Broad substrate-specific phosphorylation events are associated with the initial stage of plant cell wall recognition in Neurospora crassa

The paper investigates substrate-specific phosphorylation events in Neurospora crassa during early plant cell wall recognition using phospho-proteomics and identifies key signaling pathways and proteins involved.

A robust phylogenomic timetree for biotechnologically and medically important fungi in the genera Aspergillus and Penicillium

The paper constructs a robust phylogenomic timetree for Aspergillus and Penicillium fungi using multiple genome datasets and phylogenetic methods to identify incongruent branches and estimate divergence times.

Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species

This study identifies five types of genetic variation in secondary metabolic gene clusters across 66 strains of Aspergillus fumigatus and links them to evolutionary drivers like mutation, recombination, and horizontal gene transfer.

ploidyNGS: Visually exploring ploidy with Next Generation Sequencing data

ploidyNGS is a tool to visually determine ploidy levels in a newly sequenced genome using short read data, tested on yeast.