Spatiotemporal information is differentially conveyed by hippocampal projections to the anterior olfactory nucleus during episodic-like odour memory.

The hippocampus is essential for representing spatiotemporal context and associating it with the sensory details of daily life to form episodic memories. However, the neural circuit underlying this process remains poorly understood. We selectively inhibited hippocampal projections to the anterior olfactory nucleus (AON) during behavioural tests of contextually-cued odour recall. We found that inhibition of intermediate HPC (iHPC)-lateral AON (lAON) pathway impaired spatial odour memory while inhibition of ventral HPC (vHPC)-medial AON (mAON) pathway disrupted both spatial and temporal odour memory. Our results indicate that the spatial and temporal information of episodic-like odour memory is conveyed by topographically distinct hippocampal-AON pathways.