Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice
Zohreh Farsi, Ally A. Nicolella, Sean Simmons, Sameer Aryal, Nate Shepard, Kira S. Brenner, Sherry Lin, Linnea E. Herzog, Wangyong Shin, Vahid Gazestani, Bryan J. Song, Kevin Bonanno, Hasmik Keshishian, Steven A. Carr, Evan Z. Macosko, , Morgan Sheng
This study identifies brain region-specific changes and dopamine dysregulation in Grin2a mutant mice, supporting schizophrenia hypotheses and highlighting their utility as a genetic model.
bioRxiv · Nov 15, 2022 · PreprintNeuroscience