Scott E. Kanoski

Transsynaptic neural circuit mapping of ventral hippocampus motivational control systems

The paper maps transsynaptic circuits of ventral hippocampus neurons projecting to motivational control regions in rats using viral tracing methods.

Nutrient-dependent hippocampus dopamine signaling enhances meal-related episodic memory and reduces food intake

This study shows that hippocampal dopamine signaling after meals enhances memory of meal locations and reduces food intake in rats.

Hypothalamus amyloid levels are associated with early sex-dependent alterations in energy homeostasis in TgF344-AD rats

This study examines sex-dependent changes in energy homeostasis and amyloid levels in TgF344-AD rats, finding differences in weight gain, thermogenic function, and glucose regulation between males and females.

Consumption of processed foods impairs memory function through dietary advanced glycation end-products

This study shows that an AGE-rich diet during adolescence impairs memory via hippocampal synaptic deficits and microbiome changes, which can be mitigated by AGE inhibitors.

A ventral hippocampus to nucleus accumbens pathway regulates impulsivity

This study identifies a hippocampal-striatal circuit that regulates impulsive action in male rats, using chemogenetic and fiber photometry approaches.

Oxytocin neurons in the paraventricular and supraoptic hypothalamic nuclei bidirectionally modulate food intake

This study shows that oxytocin neurons in the paraventricular and supraoptic hypothalamic nuclei have opposing effects on food intake, with PVH neurons reducing meal size and SON neurons increasing it.

Early life food insecurity impairs memory function during adulthood

This study shows that early-life food insecurity in rats leads to memory impairments in adulthood, despite normal metabolic and behavioral outcomes.

The vagus nerve promotes memory via septo-hippocampal acetylcholine: Implications for obesity-induced cognitive dysfunction

This study shows that vagus nerve-mediated acetylcholine release in the dorsal hippocampus supports memory function, and its disruption contributes to obesity-induced cognitive impairments.

Ventral hippocampus neurons encode meal-related memory

The paper identifies ventral hippocampus neurons that encode meal-related memories and shows their role in spatial memory and feeding behavior.

Endotoxemia-induced inflammation in the absence of obesity decreases anxiety-like and impulsive behavior without affecting learning and memory

This study shows that endotoxemia-induced inflammation without obesity reduces anxiety-like and impulsive behavior but does not impair learning and memory in rats.

ATLAS: A rationally designed anterograde transsynaptic tracer

The paper introduces ATLAS, an anterograde transsynaptic tracer based on an antibody-like protein, which enables non-toxic, synaptic, and activity-dependent circuit tracing in vivo and in dissociated cultures.

Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling

This study shows that a western diet during development impairs memory by disrupting hippocampal acetylcholine signaling, which can be partially reversed with pharmacological intervention.

Hippocampus oxytocin signaling promotes prosocial eating in rats

This study shows that oxytocin signaling in the dorsal hippocampus promotes prosocial eating in rats by enhancing food consumption with familiar conspecifics and facilitating social transmission of food preference.

Hypothalamic melanin-concentrating hormone neurons integrate food-motivated appetitive and consummatory processes

This study identifies hypothalamic MCH neurons that integrate food-related appetitive and consummatory processes through physiological and behavioral responses.

Ventral hippocampus-lateral septum circuitry promotes foraging-related memory

This study identifies a neural circuit involving the ventral hippocampus and lateral septum that selectively mediates appetitive spatial memory for food or water locations.

Lasting effects of low-calorie sweeteners on glucose regulation, sugar intake, and memory

This study shows that early-life low-calorie sweetener consumption in rodents leads to long-term metabolic, behavioral, and neural impairments without weight gain.

Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long-lasting despite healthy dietary intervention

This study shows that adolescent Western diet consumption in female rats leads to long-lasting memory and gut microbiome issues that are not fully reversed by adult dietary changes.

Gut microbial taxa elevated by dietary sugar disrupt memory function

This study shows that early life sugar consumption alters gut microbiota and impairs hippocampal-dependent memory in rats, with specific bacterial taxa linked to these effects.

Central oxytocin signaling inhibits food reward-motivated behaviors and VTA dopamine responses to food-predictive cues in male rats

This study shows that central oxytocin reduces food-seeking behavior and VTA dopamine responses to food cues in male rats, but not postingestive reward value encoding.

Ghrelin signaling regulates feeding behavior, metabolism, and memory through the vagus nerve

This study shows that ghrelin signaling through vagal afferent neurons affects feeding, metabolism, and memory by targeting GHSR on these neurons.

Nucleus accumbens melanin-concentrating hormone signaling promotes feeding in a sex-specific manner

This study shows that MCH signaling in the nucleus accumbens shell promotes feeding in male rats but not females, with estradiol reducing this effect in females.