bioRxivMicrobiologyPreprint
Identification of eight SARS-CoV-2 ORF7a deletion variants in 2,726 clinical specimens
S. H. Rosenthal, R. M. Kagan, A. Gerasimova, B. Anderson, D. grover, M. Hua, R. Owen, F. Lacbawan
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF7a, the ortholog of SARS-CoV ORF7a, is a type I transmembrane protein and plays an important role in virus-host interactions. Deletion variants in ORF7a may influence virulence, but only a few such isolates have been reported. Here, we report 8 unique ORF7a deletion variants of 6 to 96 nucleotides in length identified from 2,726 clinical specimens collected in March of 2020.
- organism: human
- assay: whole-genome sequencing
- research focus: variant calling
- approach: experimental assay
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