S. Pandey

How motility drives the glassy dynamics in confluent epithelial monolayers?

This paper develops a theoretical framework to understand how motility drives glassy dynamics in epithelial monolayers, showing that confluency affects the effective persistence time-scale of active force.

Niacinamide enhances cathelicidin mediated SARS-CoV-2 membrane disruption

This study shows niacinamide enhances LL37's ability to disrupt SARS-CoV-2 membranes, suggesting it could improve AMP-based therapies for COVID-19.

Nucleo-cytoplasmic environment modulates spatio-temporal p53 phase separation

This study shows that p53 phase separation and condensate formation are modulated by the nucleo-cytoplasmic environment and cancer-associated mutations affect condensate stability and DNA binding.

Red cabbage juice-mediated gut microbiota modulation improves intestinal epithelial homeostasis and ameliorates colitis

This study shows red cabbage juice modulates gut microbiota to improve intestinal homeostasis and reduce colitis in mice by enhancing SCFA production and suppressing inflammatory pathways.

Enhanced protective efficacy of a novel, thermostable, RBD-S2 fusion immunogen against SARS-CoV-2 and its variants

This study evaluates a novel RBD-S2 fusion immunogen that shows enhanced protection against SARS-CoV-2 and its variants in animal models.

Structural analyses of 'substrate-pH of activity' pairing observed in Polysaccharide lyases

The paper investigates the relationship between substrate type and pH-dependent activity in polysaccharide lyases, identifying structural determinants of functional convergence.

Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation

The paper uses mouse models to map sepsis' effects across organs, identifying cytokine circuits and PLA2G5's role in hemolysis and organ failure.

A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice

The paper identifies a conserved population of MHC-II restricted, innate-like T cells in the gut of humans and mice that react to commensals and are implicated in colitis.

Acinetobacter baumannii represses type VI secretion system through an Mn2+-dependent sRNA-mediated regulation

This study identifies an Mn2+-dependent small RNA-mediated regulation of T6SS in A. baumannii, revealing how Mn2+ influences sRNA binding to repress T6SS.

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

This study characterizes the biased agonism of CXCR4 and CXCR7, revealing differences in G-protein coupling, β-arrestin recruitment, and ERK1/2 activation.

Activation of targetable inflammatory immune signaling is seen in Myelodysplastic Syndromes with SF3B1 mutations

This study identifies a longer, oncogenic IRAK4 isoform caused by SF3B1 mutations in MDS/AML, which is targetable by IRAK4 inhibition.

Highly Thermotolerant SARS-CoV-2 Vaccine Elicits Neutralising Antibodies Against Delta and Omicron in Mice

This study evaluates a highly thermotolerant SARS-CoV-2 vaccine in mice, showing it elicits neutralizing antibodies against Delta and Omicron variants.

Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody

This paper shows that a synthetic intrabody enhances β-arrestin endosomal trafficking and ERK1/2 activation in a GPCR mutant by promoting an active-like conformation.

Citrus Huanglongbing is an immune-mediated disease that can be treated by mitigating reactive oxygen species triggered cell death of the phloem tissues caused by Candidatus Liberibacter asiaticus

This study shows citrus Huanglongbing is an immune-mediated disease caused by CLas, where ROS-induced cell death in phloem tissues can be mitigated by antioxidants and gibberellin, reducing disease symptoms.

Vitamin C Binds to SARS Coronavirus-2 Main Protease Essential for Viral Replication

This study reports the crystal structure of SARS-CoV-2 main protease bound to Vitamin C, showing its potential as an inhibitor of viral replication.

Comparative immunogenicity of bacterially expressed soluble trimers and nanoparticle displayed influenza hemagglutinin stem immunogens

This study compares the immunogenicity of soluble trimeric influenza stem domain immunogens and nanoparticle-displayed versions, showing similar protection against homologous and heterologous viral challenges.

Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors

The paper identifies two non-canonical GPCRs, D6R and C5aR2, that exclusively couple to β-arrestins and exhibit distinct GRK preferences and downstream signaling.

Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative

This study designs a thermotolerant trimeric RBD vaccine candidate that elicits strong neutralizing antibodies against multiple SARS-CoV-2 variants in animal models.

A series of Orai1 gating checkpoints in transmembrane and cytosolic regions requires clearance for CRAC channel opening

This study identifies Orai1 gating checkpoints that must be cleared for CRAC channel opening, using a library of double mutants and structural analysis.

Estimation of the Acetylcholinesterase activity of honey bees in Nepal

This study measures Acetylcholinesterase activity in honey bees from Nepal, finding increased AChE and protein levels in winter samples and species-specific differences.

Direct Observation of the Mechanism of Antibiotic Resistance by Mix-and-Inject at the European XFEL

The paper directly observes fast ligand binding in a biomedically relevant enzyme using MHz X-ray pulses at the European XFEL.

High-resolution Crystal Structures of Transient Intermediates in the Phytochrome Photocycle

The paper captures high-resolution crystal structures of transient phytochrome intermediates to elucidate the structural changes during the Pr-to-Pfr photocycle.

Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment

This paper designs a thermotolerant, immunogenic SARS-CoV-2 RBD protein fragment that is stable at high temperatures and elicits neutralizing antibodies in guinea pigs.

Ebselen Reacts with SARS Coronavirus-2 Main Protease Crystals

This paper shows that Ebselen inhibits SARS-CoV-2 main protease 3CLpro by destroying its crystal diffraction power, suggesting it as a potential antiviral agent.

Identification of unique mutations in SARS-CoV-2 strains isolated from India suggests its attenuated pathotype

The paper identifies unique mutations in SARS-CoV-2 strains from India, suggesting an attenuated pathotype with implications for vaccine development.

Induction of intracellular wild-type p53 amyloids leading to cellular transformation and tumor formation in mice

This study shows that wild-type p53 amyloid formation leads to cellular transformation and tumor formation in mice by enhancing survival, proliferation, and migration while suppressing tumor suppressors.

Insight towards the effect of the multibasic cleavage site of SARS-CoV-2 spike protein on cellular proteases

This study investigates how mutations in the multibasic cleavage site of SARS-CoV-2 spike protein affect interactions with host proteases, suggesting potential strategies for attenuating the virus and developing antivirals.

A receptor-like kinase mediated phosphorylation of Gα protein affects signaling during nodulation

This study shows that SymRK phosphorylates Gα in soybean, disrupting GTP binding and altering interactions with Gβγ, thereby regulating G-protein signaling during nodulation.

Genetic identification of the functional surface for RNA binding by Escherichia coli ProQ

This study identifies conserved residues on ProQ's NTD as the primary RNA-binding face using bacterial three-hybrid assays and genetic screens.

The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser

This study captures the structural changes in bacterial phytochrome proteins after light exposure using femtosecond X-ray crystallography, revealing key molecular movements involved in the photoresponse.