Sk. Sarif Hassan

Mathematical genomics of SRY proteins and their associated HMG-Box domains across mammals

The paper quantifies compositional patterns in SRY proteins and HMG-box domains across mammals, revealing distinct compositional grammars and highlighting the need for alignment-independent analysis.

Quantitative Deciphering of Mammalian Histamine Receptors through Mathematical Genomics

This study analyzes mammalian histamine receptor sequences to identify evolutionary patterns and structural constraints across species.

CpG-induced regions associated compositional stratification of human essential proteins through mathematical genomics

The paper analyzes the impact of CpG island architecture on amino acid usage and sequence complexity in human essential proteins, revealing compositional stratification and positional biases.

A Mathematical Genomics Perspective on the Moonlighting Role of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH)

This study analyzes 165 GAPDH sequences to show that multifunctionality is encoded through compositional signatures and conserved spatial architecture, enabling metabolic stability and regulatory plasticity.

Proximal relationships of moonlighting Proteins in Escherichia coli: a mathematical genomic perspective

This study quantitatively analyzes E. coli moonlighting proteins to identify patterns in amino acid composition and structural-functional relationships.

Molecular Genomic Insights into Melanoma Associated Proteins PRAME and BAP1

This study analyzes the molecular features of PRAME and BAP1 proteins in melanoma using bioinformatics methods to identify potential therapeutic targets.

Methuselah Proteins in Longevity: Unraveling Their Impact Through Mathematical Genomics

This study analyzes 18 Methuselah protein variants in fruit flies, identifying evolutionary clades, functional subclasses, and structural features related to aging and longevity.

Unveiling the Genetic Tapestry: Rare Disease Genomics of Spinal Muscular Atrophy and Phenylketonuria Proteins

This study analyzes genetic variations in PAH and SMN1 genes associated with PKU and SMA in Saudi Arabia using quantitative techniques to improve diagnostics and treatments.

SARS-CoV-2 NSP14 governs mutational instability and assists in making new SARS-CoV-2 variants

This study analyzes NSP14 mutations in SARS-CoV-2 to understand their role in viral evolution and variant diversification.

The Distal-Proximal Relationships Among the Human Moonlighting Proteins: Evolutionary hotspots and Darwinian checkpoints

This study analyzes human moonlighting proteins using phylogenetic methods to explore their distal-proximal relationships and identify evolutionary hotspots.

Biology of Coital Behavior: Looking Through the Lens of Mathematical Genomics

The paper investigates receptor sequences across vertebrate species to understand their relationship with mating behavior, finding that genetic and epigenetic factors influence behavioral patterns beyond direct genomic translation.

SARS-CoV-2 variants show a gradual declining pathogenicity and pro-inflammatory cytokine spur, an increasing antigenic and anti-inflammatory cytokine induction, and rising structural protein instability

The paper analyzes SARS-CoV-2 variants to show decreasing pathogenicity and pro-inflammatory cytokines, increasing antigenicity and anti-inflammatory cytokines, and rising structural protein instability across variants.

Possible Functional Proximity of Various Organisms Based on Taste Receptors Genomics

The paper compares sweet and bitter taste receptor genomics across 20 vertebrates to assess functional proximity and ligand binding affinity similarities.

An Issue of Concern: Unique Truncated ORF8 Protein Variants of SARS-CoV-2

The paper identifies 47 unique truncated ORF8 protein variants in B.1.1.7 SARS-CoV-2 sequences and defines nine possible variants based on physicochemical properties.

Implications Derived from S-Protein Variants of SARS-CoV-2 from Six Continents

The paper analyzes S-protein variants of SARS-CoV-2 from six continents, finding North America has the most unique variants, which may spread globally, suggesting travel restrictions and vaccine updates are needed.

Pathogenetic Perspective of Missense Mutations of ORF3a Protein of SARS-CoV2

The paper identifies and analyzes 175 non-synonymous mutations in the ORF3a protein of SARS-CoV2, classifying them into neutral, disease, and mixed types and detecting 20 clusters using K-means clustering.

Notable sequence homology of the ORF10 protein introspects the architecture of SARS-COV-2

The paper analyzes sequence variations and structural properties of SARS-CoV-2 ORF10 protein to assess its role in viral pathogenicity and potential as a pharmaceutical target.

A unique view of SARS-CoV-2 through the lens of ORF8 protein

This study analyzes the ORF8 protein of SARS-CoV-2 and its mutations across human, bat, and pangolin hosts to understand its role in immune evasion and evolutionary dynamics.

Clade GR and Clade GH Isolates in Asia Show Highest Amount of SNPs

The paper analyzes SARS-CoV-2 isolates from ten Asian countries to identify mutations and assess their functional impact across different clades.

Possible transmission flow of SARS-CoV-2 based on ACE2 features

The paper analyzes ACE2 receptors across nineteen species to propose a possible SARS-CoV-2 transmission flow based on receptor-binding domain interactions.

Variability of Accessory Proteins Rules the SARS-CoV-2 Pathogenicity

The paper analyzes variations in SARS-CoV-2 accessory proteins across global proteomes and finds ORF3a has the highest unique variations, suggesting these variations may influence pathogenicity.

Molecular conservation and Differential mutation on ORF3a gene in Indian SARS-CoV2 genomes

The paper analyzes mutations in the ORF3a gene of Indian SARS-CoV2 genomes, finding single and double point mutations that may affect virulence and suggesting therapeutic implications.

On spatial molecular arrangements of SARS-CoV2 genomes of Indian patients

The paper compares SARS-CoV2 genomes from India and China to analyze spatial and molecular arrangements, revealing potential differences in viral origins and evolution.

Distribution of Purines and Pyrimidines over miRNAs of Human, Gorilla and Chimpanzee

The paper analyzes the distribution of purines and pyrimidines in miRNAs across human, gorilla, and chimpanzee, identifying non-random patterns and clustering based on quantitative metrics.

The variations of human miRNAs and Ising like base pairing models

The paper analyzes nucleotide base distributions in human miRNAs and proposes an Ising-like model to explain their non-random sequence variations.