Dinesh Kumar

This study investigates GPR17's role in oligodendrocyte precursor cell maturation and myelin regeneration, finding limited impact on myelin repair after injury.

The paper identifies novel pathways that enhance oligodendrocyte maturation and myelination through high-throughput screening of 2500 compounds using engineered human stem cell-derived OPCs.

The paper shows microglia are susceptible to ferroptosis in neurodegenerative diseases and identifies SEC24B and small molecules that regulate this process.

This study identifies mutations in the NTD of the SARS-CoV-2 spike protein in the B.1.617.2 variant that reduce antibody binding and suggest immune evasion.

The paper profiles single nuclei from human putamen in Parkinson's Disease and Multiple System Atrophy, revealing disease-specific oligodendrocyte heterogeneity and gene expression changes.

The paper constructs a single-cell atlas of human putamen tissue from healthy controls, Parkinson's Disease, and Multiple System Atrophy to identify cell-type specific disease changes.

The paper analyzes SARS-CoV-2 genomes from Gujarat to identify variants associated with mortality and pathogenesis, finding specific mutations linked to increased disease severity.

The paper analyzes single-cell RNA-seq data from COVID-19 patients to identify the lysosomal-immune axis as a factor associated with disease severity.

This paper computes a genome-wide polygenic risk score for Parkinson's Disease using 6.2 million variants and finds it strongly associates with increased disease risk and earlier onset.

The paper identifies a conserved SNCA co-expression module in human brain single-nucleus RNA-seq data and links it to Parkinson's Disease risk loci through protein-protein interaction networks and CRISPR validation.