Antigenic landscape of a highly mutated SARS-CoV-2 Spike in ongoing viral evolution
Priscilla Turelli, Elise Eray, Charlène Raclot, Didier Trono, Aleksandar Antanasijevic
This study examines how mutations in the N-terminal domain of SARS-CoV-2 Spike affect antigenic properties and immune escape, finding that structural flexibility and loss of heme-metabolite interaction reduce antibody neutralization.
Proceedings of the National Academy of Sciences · Oct 28, 2026Peer-reviewedImmunology