Scaling up submerged fermentation process of Aspergillus fumigatus MGA for an efficient metabolite production (xylanase)

Abstract

Fungal metabolites production at an industrial scale requires a sufficient yield at relatively low cost. Indeed, the scaling-up process is one of the main bottlenecks in the fermentation procedure; the reproduction of the best conditions achieved in small bio-reactors when transferring them to a much larger fermentation scale is near impossible. The present study seeks to study the fermentation profile of Aspergillus fumigatus fungi, in order to spot it logarithmic phase using xylose as substrate in different volumes; 250 mL flasks, 2 L and 20 L bioreactors, before conducting further experiments for an efficient secondary metabolite production (xylanase). The agitation speed impact on the morphological changing of this fungi was also studied.