Multiregional Representations of Intertemporal Decision Making in Human Single Neurons

Characterization of the neural basis of delay discounting provides insight into the origin of impulsive decision-making, which underlies several psychiatric diseases including substance use disorder. Here, we identify human single unit representations of decisions, and their level of difficulty, in the orbitofrontal cortex, hippocampus and amygdala that are related to preferences for immediate vs. delayed rewards. Results provide an initial account of multiregional intracranial computations related to impulsive behaviors in humans.