Sex-specific insights into drug-induced lifespan extension and weight loss in mice

Abstract

The DrugAge database serves as a comprehensive resource for the study of compounds that increase lifespan in model organisms. In the latest version of DrugAge, we have implemented multiple updates, predominantly focusing on mouse (Mus musculus) studies to enhance data accuracy and consistency. Key improvements include the re-recording of mouse data from original sources, standardization of drug dosages to parts per million (ppm), and detailed recording of administration routes, treatment initiation ages, and durations. The user interface has also been upgraded. Additionally, weight change data were included to address the potential impact of caloric restriction induced by drug administration on lifespan. Our analysis revealed significant correlations between weight loss and lifespan extension in male mice, particularly in studies conducted by the Interventions Testing Program (ITP), highlighting the importance of considering weight change in lifespan studies. We also observed notable sex-related differences in lifespan and weight change responses, underscoring the need for gender-specific analyses in aging research.