Robert W. Williams

This study identifies time-dependent epistatic interactions between Oprm1 and Fgf12 that modulate opioid-induced locomotion in mice and links Fgf12 to opioid behavior in humans.

This study characterizes the BXD51 mouse strain as a reproducible model of chronic progressive glaucoma, showing distinct clinical and structural features compared to other strains.

This study evaluates three deep learning models for optic nerve axon quantification on a novel rat dataset, finding reduced performance compared to published benchmarks.

This study identifies genetic loci affecting lifespan dynamics, sex differences, and body weight trade-offs in mice using an actuarial approach.

MONICA is a web-based tool that automatically extracts optic nerve boundaries and calculates morphometric metrics, validated across species and image qualities.

The paper identifies the Pgb1 locus as controlling glycogen aggregation in aged hippocampal astrocytes without affecting cognitive function.

The paper identifies genome-wide promoter-enhancer interactions in rat brain using Hi-C data and CTCF binding sites, revealing regulatory elements linked to developmental processes.

GNQA, a retrieval-augmented GPT question-answering system over 3000 GeneNetwork, aging and diabetes papers, cites source paragraphs; RAGAS rated answer relevance above human thumbs-up ratings (89% vs 76%).

This paper uses IBD-based clustering to reveal environmental and health disparities across subcommunities in a biobank dataset.

This study examines how genetic factors and sex influence oxycodone self-administration in rats, finding sex differences in intake and heritability in specific strains.

This study quantifies protein expression in rat brains, identifies pQTLs, and links them to behavioral traits and human disorders.

The paper presents a Hi-C dataset from rat frontal cortex to study strain-specific chromatin architecture and its impact on gene expression and neurological traits.

This study constructs a rat pangenome from linked-read data to enhance variant discovery and genotype-phenotype mapping in recombinant inbred strains.

This study quantifies the impact of Alzheimer's disease mutations on brain regions in mice, revealing bidirectional volume changes and sex-specific effects.

The paper analyzes genomic data from a diverse cohort to highlight genetic diversity and disparities in disease prevalence linked to ancestry and environment.

This paper introduces PGGB, a pipeline for building pangenome graphs that includes all variation without bias, enabling variation detection, conservation measurement, recombination event detection, and phylogenetic inference.

The paper creates a multimodal 3D mouse brain atlas using MR histology and light sheet microscopy, improving spatial resolution and enabling stereotaxic labeling of brain images.

The paper presents an improved rat reference genome, mRatBN7.2, which enhances genomic, transcriptomic, and proteomics data mapping and identifies millions of genetic variations across rat strains.

The paper investigates genetic and sex differences in stress and morphine responses across mouse strains and their progeny, finding genetic influences on stress vulnerability and morphine sensitivity.

The paper develops a novel murine model to identify genetic modifiers of triple-negative breast cancer traits and identifies susceptibility loci with potential translational relevance.

The paper presents a scalable pipeline for reference genome assembly and evaluation, demonstrating its effectiveness across 51 vertebrate species using Galaxy.

GenomeMUSter integrates and harmonizes mouse genetic variation data across populations to enable multi-trait, multi-population analyses and improve variant-phenotype association studies.

BulkLMM accelerates genome-wide scans for multiple quantitative traits using LMMs by employing vectorized operations and regularization, achieving fast results on large datasets.

This paper introduces a workflow combining light sheet microscopy and magnetic resonance histology to accurately count neurons and assess neuronal density in mouse brains, showing improved accuracy and broad applicability.

RNA Strain-Match matches RNA sequencing alignment data to genotype without variant call files, correcting 13% of sample mismatches in mouse models.

The paper uses transposon mutagenesis and QTL mapping to identify host-pathogen genetic interactions affecting Mtb fitness in immunodivergent mice.

The paper identifies a quantitative trait locus on chromosome 13 associated with STR expansion propensity in mice, implicating Msh3 in genome-wide mutation patterns.

The paper compares risky decision-making and impulsivity between two Lewis rat substrains, finding significant phenotypic differences linked to genetic variants.

This study uses QTL analysis in BXD mice to identify genetic loci associated with motor coordination traits similar to human DCD.

This study uses BXD mice and QTL analysis to identify genetic factors linked to motor learning traits resembling developmental coordination disorder.