R. A. Miller

Soquelitinb, A selective inhibitor of interleukin-2-inducible kinase (ITK), is active in several murine models of T cell-mediated inflammatory disease

This study shows that soquelitinib inhibits ITK and reduces T cell-mediated inflammation in multiple murine models.

Selective inhibition of interleukin-2 inducible T cell kinase (ITK) enhances anti-tumor immunity in association with Th1-skewing, cytotoxic T cell activation, and reduced T cell exhaustion

Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging

This study evaluates the effects of methylene blue and mitoquinone on skeletal aging in mice, finding no significant reduction in age-related bone loss despite some in vitro benefits.

Evolution of High-Molecular-Mass Hyaluronic Acid is Associated with Subterranean Lifestyle

The paper identifies that subterranean mammals have abundant high-molecular-mass HA due to genetic changes, which may aid in cancer resistance and adaptation to hypoxic environments.

Late-life isoleucine restriction promotes physiological and molecular signatures of healthy aging

This study shows that reducing amino acids or isoleucine in the diet of aged mice improves metabolic health, reduces frailty, and slows aging markers.

Lifespan Extension in Female Mice By Early, Transient Exposure to Adult Female Olfactory Cues

This study shows that exposing female mice to adult female odors during early life extends their lifespan, while male lifespan is unaffected by such odors.

Aging is associated with increased brain iron through brain-derived hepcidin expression

This study shows that aging increases brain iron levels through elevated local hepcidin expression, leading to reduced iron export and accumulation in both cytosolic and mitochondrial compartments.

Characterizing interactions between the microtubule-binding protein CLIP-170 and F-actin

This study shows CLIP-170 directly binds F-actin, independent of formin interaction, and suggests this binding may reduce MT stability in actin-rich regions.

Canagliflozin increases adenoma burden in female APCMin/+ mice

This study shows that canagliflozin increases adenoma burden in female APCMin/+ mice, suggesting complex, cell-non-autonomous mechanisms and sex differences in drug effects.

Muribaculaceae genomes assembled from metagenomes suggest genetic drivers of differential response to acarbose treatment in mice

The paper identifies genetic factors in Muribaculaceae bacteria that correlate with differential response to acarbose treatment in mice using metagenome-assembled genomes.

Canagliflozin Extends Lifespan in Genetically Heterogeneous Male But Not Female Mice

This study shows canagliflozin extends lifespan in male but not female mice, likely by reducing peak glucose levels, similar to acarbose.

Changes in the gut microbiota and fermentation products associated with enhanced longevity in acarbose-treated mice

This study shows that acarbose treatment in mice increases gut microbiota-derived short-chain fatty acids, which correlate with longer lifespan, suggesting a role for microbiota in acarbose's longevity effects.