A general decrease of normalized ncDNA in evolution

Complexity is often associated with increasing non-coding DNA (ncDNA). For example, the human genome is in its vast majority ncDNA. Here, it is hypothesized that normalized ncDNA (nncDNA) has in fact diminished in evolution. This definition of ncDNA content takes into consideration total proteomic content. It is shown that by reducing their normalized ncDNA, organisms may have obtained more complexity in evolution. Also, a potential connection between ncDNA, proteome information and chromatin interactions in mice and humans is presented.