Author

Y. Pichugin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 10 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 9 Approach:experimental assay· 4 Organism:bacteria (other)· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:imaging· 1

Frequent Co-Authors

A. Traulsen· 8 shared Y. Gao· 4 shared H. J. Park· 3 shared B. Werner· 2 shared K. Hammerschmidt· 2 shared W. Huang· 2 shared A. G. Henssen· 1 shared C. J. Rose· 1 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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8 shared papersEvolutionary Biology

A. Traulsen

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Author profile →

12 papers

Recent·Most cited

Evolution of irreversible differentiation under stage-dependent cell differentiation

Y. Gao, R. Zapien-Campos, Y. Pichugin, A. Traulsen

This paper develops a theoretical model to study how stage-dependent cell differentiation affects the evolution of optimal differentiation patterns, finding that irreversible differentiation is favored in small organisms.

bioRxiv · May 4, 2023Evolutionary Biology

Eco-evolutionary dynamics of clonal multicellular life cycles

V. Ress, A. Traulsen, Y. Pichugin

This study presents a model of colonial life cycles evolution that incorporates group interactions, showing that coexistence of life cycles or initial state dependence can occur, which simpler models without interactions cannot capture.

bioRxiv · Mar 14, 2022Evolutionary Biology

Phenotypic plasticity, life cycles and the evolutionary transition to multicellularity

S. Tang, Y. Pichugin, K. Hammerschmidt

The paper identifies an environmentally driven facultative multicellular life cycle in Cyanothece sp. ATCC 51142, showing that filament dissolution is triggered by environmental changes and modeled as a density-dependent sensing system.

bioRxiv · Sep 29, 2021 · PreprintEvolutionary Biology

Evolution of reproductive strategies in incipient multicellularity

Y. Gao, Y. Pichugin, C. S. Gokhale, A. Traulsen

The paper develops a population model to analyze optimal reproductive strategies in incipient multicellular organisms, finding that organism size and cellular interaction influence reproductive success.

bioRxiv · Sep 13, 2021Evolutionary Biology

Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers

J. T. Lange, C. Y. Chen, Y. Pichugin, F. Xie, J. Tang, K. L. Hung, K. E. Yost, Q. Shi, M. L. Erb, U. Rajkumar, S. Wu, C. Swanton, Z. Liu, W. Huang, H. Y. Chang, , P. S. Mischel

bioRxiv · Jun 11, 2021 · PreprintCancer Biology

Evolution of irreversible somatic differentiation

Y. Gao, H. J. Park, A. Traulsen, Y. Pichugin

This study develops an evolutionary model showing that costly cell differentiation, beneficial vegetative cells, and sufficient organism size are necessary for irreversible somatic differentiation.

bioRxiv · Jan 18, 2021Evolutionary Biology

Why is cyclic dominance so rare?

H. J. Park, Y. Pichugin, A. Traulsen

The paper investigates why cyclic dominance is rare in nature by showing that it is more likely to emerge when new types are unrelated to existing ones rather than similar.

bioRxiv · May 7, 2020Evolutionary Biology

Meta-population structure and the evolutionary transition to multicellularity

C. J. Rose, K. Hammerschmidt, Y. Pichugin, P. B. Rainey

The paper shows that structured environments favor the evolution of multicellularity by maintaining group and dispersal phase discreteness in bacterial populations.

bioRxiv · Apr 30, 2020Evolutionary Biology

Stochastic dynamics of extra-chromosomal DNA

Y. Pichugin, W. Huang, B. Werner

This study develops a theoretical framework to model the evolutionary dynamics of extra-chromosomal DNA in cancer, showing that random segregation can lead to complex dynamics even under strong selection.

bioRxiv · Dec 15, 2019 · PreprintCancer Biology

Evolution of simple multicellular life cycles in dynamic environments

Y. Pichugin, H. J. Park, A. Traulsen

This study develops a framework to analyze how simple multicellular life cycles evolve in dynamic environments, finding that deterministic reproduction modes are favored over stochastic ones.

bioRxiv · Apr 8, 2019Evolutionary Biology

Interacting cells driving the evolution of multicellular life cycles

Y. Gao, A. Traulsen, Y. Pichugin

This study uses evolutionary game theory to identify optimal life cycles for multicellular evolution, finding that only eight life cycles maximize population growth rate.

bioRxiv · Jan 29, 2019Evolutionary Biology

Fragmentation modes and the evolution of life cycles

Y. Pichugin, J. Pena, P. Rainey, A. Traulsen

The paper models fragmentation modes in reproduction and finds that life cycles maximizing population growth rate include unicellular propagule production and division into two similar size groups.

bioRxiv · Nov 21, 2017Evolutionary Biology