Information flow, cell types and stereotypy in a full olfactory connectome

Philipp Schlegel; Alexander Shakeel Bates; Tomke Stürner; Sridhar R. Jagannathan; Nikolas Drummond; Joseph Hsu; Laia Serratosa Capdevila; Alexandre Javier; Elizabeth C. Marin; Asa Barth‐Maron; Imaan FM Tamimi; Feng Li; Gerald M. Rubin; Stephen M. Plaza; Marta Costa; Gregory S.X.E. Jefferis

doi:10.7554/elife.66018

NeuroscienceeLifeMay 25, 2021

Peer-reviewed journal article

Information flow, cell types and stereotypy in a full olfactory connectome

Philipp Schlegel iD, Alexander Shakeel Bates iD, Tomke Stürner iD, Sridhar R. Jagannathan iD, Nikolas Drummond iD, Joseph Hsu iD, Laia Serratosa Capdevila iD, Alexandre Javier iD, Elizabeth C. Marin iD, Asa Barth‐Maron iD, Imaan FM Tamimi iD, Feng Li iD, Gerald M. Rubin iD, Stephen M. Plaza iD, Marta Costa iD, Gregory S.X.E. Jefferis iD

PDF DOI Preprint

Post to X

Threads on X Post to Bluesky Threads on Bluesky

Abstract

The hemibrain connectome provides large scale connectivity and morphology information for the majority of the central brain of Drosophila melanogaster. Using this data set, we provide a complete description of the Drosophila olfactory system, covering all first, second and lateral horn-associated third-order neurons. We develop a generally applicable strategy to extract information flow and layered organisation from connectome graphs, mapping olfactory input to descending interneurons. This identifies a range of motifs including highly lateralised circuits in the antennal lobe and patterns of convergence downstream of the mushroom body and lateral horn. Leveraging a second data set we provide a first quantitative assessment of inter - versus intra-individual stereotypy. Comparing neurons across two brains (three hemispheres) reveals striking similarity in neuronal morphology across brains. Connectivity correlates with morphology and neurons of the same morphological type show similar connection variability within the same brain as across two brains.