Allele frequency distribution of SNPs associated with levels of Vitamin D-binding protein and 25-hydroxyvitamin D

Haplotypes defined by rs7041/rs4588 in GC gene modulate 25-hydroxyvitamin D (25(OH)D) and vitamin D-binding protein (DBP) levels. To investigate the distributions of GC polymorphisms, the rs7041 and rs4588 allele and haplotypes frequencies were analyzed in samples from different Eurasian regions. The GC1S haplotype associated with high level of serum 25(OH)D had the maximum frequency in European populations (except Finish population). Such frequency distributions may be a result of adaptation to low solar insolation rate. Besides, there was a strong trend of increasing GC1F haplotype frequency from Europe (10-15%) to Siberia and Easter Asia (40-45%).