John Joseph McGrath

Succinate enhances mitochondrial metabolism and phagocytosis in human airspace monocytes

The paper identifies mitochondrial metabolism as a key regulator of phagocytic function in human lung monocytes and macrophages, showing that succinate supplementation enhances these functions and promotes macrophage differentiation.

The genetic and phenotypic correlates of neonatal Complement Component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders

This study examines the genetic and phenotypic links between neonatal C3 and C4 protein concentrations and psychiatric and autoimmune disorders, finding no strong causal associations with mental disorders but evidence of lower autoimmune risk with higher C4 levels.

ADuLT: An efficient and robust time-to-event GWAS

ADuLT is a time-to-event GWAS method that outperforms Cox regression in strongly ascertained studies, finding more genome-wide significant associations in psychiatric disorder analyses.

Identification of 64 new risk loci for major depression, refinement of the genetic architecture and risk prediction of recurrence and comorbidities

This study identifies 64 new risk loci for major depression, refines its genetic architecture, and shows strong genetic overlap with other psychiatric disorders and educational attainment.

Genetic correlates of vitamin D-binding protein and 25 hydroxyvitamin D in neonatal dried blood spots

This study identifies genetic loci associated with vitamin D-binding protein and 25 hydroxyvitamin D in neonates and links DBP to vitamin D status and disease risk.

Multi-PGS enhances polygenic prediction: weighting 937 polygenic scores

This paper introduces a framework to enhance polygenic prediction by combining multiple polygenic scores, showing significant accuracy improvements for psychiatric disorders and other traits.

Accounting for age-of-onset and family history improves power in genome-wide association studies

This paper introduces LT-FH++, a method that improves GWAS power by incorporating age-of-onset and family history, showing increased significant associations in psychiatric disorders and mortality data.

Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

This study compares methods for combining GWAS summary statistics and individual-level data to improve polygenic prediction, finding that Meta-PRS is often more accurate than Meta-GWAS.

Efficient toolkit implementing best practices for principal component analysis of population genetic data

The paper presents best practices and efficient implementations for PCA of genetic data to address issues like LD structure capture, shrinkage bias, and population structure confounding.

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

This study identifies 143 genetic loci associated with 25 hydroxyvitamin D concentration in Europeans, revealing biological pathways and causal relationships with health outcomes.

A Whole-Genome Approach Discovers Novel Genetic and Non-Genetic Variance Components Modulated by Lifestyle for Cardiovascular Health

This study uses a whole-genome approach to identify genetic and non-genetic variance components in cardiovascular risk influenced by lifestyle factors, showing their modulating effects and implications for CVD prevention.

Paternal-age-related de novo mutations and risk for five disorders

The paper estimates the risk of five disorders from paternal-age-related de novo mutations using whole-exome-sequencing data and Danish registry data.

The Australian Genetics of Depression Study: Study Description and Sample Characteristics

The paper describes the recruitment and characteristics of a large cohort of individuals with depression, highlighting the study's effectiveness in gathering data for genetic and environmental risk factor analysis.

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

This study uses conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders, finding some variants with reduced pleiotropy effects.

Higher genetic risk for schizophrenia is associated with living in urban and populated areas

The paper finds a genetic association between schizophrenia risk and urban living, suggesting genetic factors influence migration to densely populated areas.

Causal associations between risk factors and common diseases inferred from GWAS summary data

This study uses genetic data to identify causal relationships between risk factors and common diseases, finding protective and bidirectional effects.

The iPSYCH2012 case-cohort sample: New directions for unravelling genetic and environmental architectures of severe mental disorders

The paper introduces the iPSYCH2012 case-cohort sample, a large Danish population-based dataset for studying genetic and environmental factors in severe mental disorders.