Vitamin D Research Studies

XPO1 controls VDR localization and activity in triple-negative breast cancer cells

This study shows XPO1 regulates VDR subcellular localization and vitamin D responsiveness in TNBC, with XPO1 inhibition enhancing vitamin D's antiproliferative effects.

Vitamin D counters bone invasion by mammary cancer through inhibition of inflammation and epithelial-to-mesenchymal transition

This study shows vitamin D deficiency accelerates bone invasion in mammary cancer by increasing inflammation and epithelial-to-mesenchymal transition, while vitamin D repletion reduces these effects.

The Potential Effect of Vitamin D Supplement on Selected Coagulability Predictors in Vape-Exposed Female Rats

This study examines how vitamin D supplementation affects coagulation markers and organ function in vape-exposed female rats, finding that high-dose vitamin D reduces inflammation and coagulation factors.

Serum IL-6 and IL-18 Responses in Pediatric COVID-19: Role of Vitamin D Status in a Cohort from Azerbaijan

This study examines the relationship between vitamin D status and cytokine levels in children with COVID-19, finding no statistically significant association but noting higher cytokine levels in infected children.

Genomic profiling of active vitamin D colonic responses in African- and European-Americans identifies an ancestry-related regulatory variant of POLB

The paper identifies an ancestry-related regulatory variant of POLB associated with 1,25D responses in colonic organoids from African- and European-Americans.

Cholecalciferol Ameliorates Cyclophosphamide-induced Behavioural Toxicities in Wistar Rats

This study shows that cholecalciferol reduces cyclophosphamide-induced anxiety and improves spatial memory in rats, suggesting its potential as an adjunct in cancer treatment.

Attenuative effect of Grifola frondosa (maitake mushroom) on severe DSS-induced colitis in vitamin D-deficient mice

This study shows that maitake mushroom improves vitamin D status and reduces DSS-induced colitis in vitamin D-deficient mice, comparable to vitamin D2 supplementation.

OSBPL11 is an African-specific locus associated with 25-hydroxyvitamin D concentrations and cardiometabolic health

The paper identifies a novel genetic locus OSBPL11 associated with vitamin D levels and cardiometabolic health in African populations through genome-wide analysis.

Inhibition of lysine deacetylase activity impacts formation of the vitamin D receptor activation complex.

The paper shows that lysine deacetylase activity affects VDR's ability to form an activation complex, altering its transcriptional output.

VDR-calcium axis regulates the diet-driven metabolic shift during weaning

This study shows that the VDR-calcium axis is critical for metabolic adaptation during weaning, with dietary fat preventing energy deprivation in VDR-deficient mice.

Exploring vitamin D and its analogues as a possible therapeutic intervention in targeting inflammatory mediators in neurodegenerative disorders like Parkinsons disease

This study investigates the interactions of vitamin D and its analogues with inflammatory mediators in Parkinson's disease to explore their potential as therapeutic agents for neuroinflammation.

Associations Between Prenatal Vitamin D and Placental Gene Expression

This study examines the association between prenatal vitamin D levels and placental gene expression, finding 25 differentially expressed genes linked to mid-pregnancy vitamin D levels.

The metabolic role of vitamin D in children's neurodevelopment: a network study

This study investigates the metabolic role of vitamin D in children's neurodevelopment using a network approach, finding associations between vitamin D deficiency and changes in tryptophan, linoleic, and fatty acid metabolism linked to ASD-related phenotypes.

Variants in Vitamin D-related Genes and Prostate Cancer Risk in Black Men

This study examines the association between vitamin D-related gene variants and prostate cancer risk in Black men, finding no significant associations after adjustment but some suggestive results.

Altered liver metabolism post-wean abolishes efficacy of vitamin D for breast cancer prevention in a mouse model

This study shows that vitamin D's anti-cancer effects are reduced in post-wean mice due to altered liver metabolism, highlighting the importance of reproductive history in treatment efficacy.

Prenatal vitamin D deficiency alters immune cell proportions of young adult offspring through alteration of long-term stem cell fates

This study shows prenatal vitamin D deficiency changes immune cell proportions in offspring by altering hematopoietic stem cell transcriptional properties and confirms maternal vitamin D levels affect cord blood immune profiles.

Genetic correlates of vitamin D-binding protein and 25 hydroxyvitamin D in neonatal dried blood spots

This study identifies genetic loci associated with vitamin D-binding protein and 25 hydroxyvitamin D in neonates and links DBP to vitamin D status and disease risk.

Common genetic variant of GC associated with vitamin D deficiency in a Chinese population in the Netherlands

The paper investigates a genetic variant in GC associated with vitamin D deficiency in a Chinese population in the Netherlands, finding a significant association after meta-analysis.

Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1

The paper shows vitamin D regulates two chromosomal loci linked to autoimmune and inflammatory diseases by modulating gene expression and immune pathways.

Oral Vitamin D supplementation induces transcriptomic changes in rectal mucosa that are consistent with anti-tumour effects.

This study shows oral vitamin D supplementation changes rectal mucosa gene expression patterns linked to anti-tumor effects, with blood biomarkers HIPK2 and PPP1CC identifying responders.

The causal role of circulating vitamin D concentrations in human complex traits and diseases: a large-scale Mendelian randomization study

This study uses Mendelian randomization to assess the causal effect of vitamin D on various traits and diseases, finding significant protective effects against multiple sclerosis but limited evidence for other outcomes.

Remote testing of vitamin D levels across the UK MS population - a case control study

This study compares vitamin D levels between people with multiple sclerosis and controls in the UK using remote sampling, finding higher levels in MS patients due to supplementation.

Evidence of a dysregulated Vitamin D pathway in SARS-CoV-2 infected patient's lung cells

The paper uses transcriptomic data to show reduced vitamin D pathway components and 107 downregulated genes in SARS-CoV-2 infected lung cells, suggesting dysregulation of the pathway in infection.

Vitamin D receptor (VDR) gene FokI, BsmI, ApaI and TaqI polymorphisms and osteoporosis risk: a meta-analysis

This study performs a meta-analysis of VDR gene polymorphisms and osteoporosis risk, finding significant associations for FokI in overall analysis and TaqI in Caucasian populations.

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

This study identifies 143 genetic loci associated with 25 hydroxyvitamin D concentration in Europeans, revealing biological pathways and causal relationships with health outcomes.

Multi-ethnic analysis shows genetic risk and environmental predictors interact to influence 25(OH)D concentration and optimal vitamin D intake

This paper investigates gene-environment interactions affecting vitamin D levels and optimal intake across different ethnic groups.

Polymorphisms in the vitamin D system and mortality - The Tromso study

The paper investigates the association between vitamin D-related SNPs and mortality using the Tromso Study, finding a weak causal link and a significant SNP in the CUBILIN gene.

Vitamin D3 regulates estrogen’s action and affects mammary epithelial organization in 3D cultures

This study investigates how vitamin D3 affects mammary epithelial organization in 3D cultures, showing its role in modulating estrogen's actions and collagen fiber organization.

Allele frequency distribution of SNPs associated with levels of Vitamin D-binding protein and 25-hydroxyvitamin D

The paper analyzes allele and haplotype frequencies of GC gene polymorphisms in Eurasian populations to explore their association with vitamin D levels and potential adaptation to solar insolation.