bioRxivMolecular BiologyPreprint
Xist lncRNA forms silencing granules that induce heterochromatin formation and repressive complexes recruitment by phase separation
Andrea CeraseiD, Alexandros ArmaosiD, Fernando Cid, Philip R. Avner, Gian Gaetano TartagliaiD
Abstract
Main text Main text Microscopy RNA Structure Protein-RNA interactions Granule propensity Material and methods in... References Long non-coding RNAs (lncRNAs) are RNA molecules longer than 200 bases that lack coding potential1,2. They represent a significant portion of the cell transcriptome3 and work as activators or repressors of gene transcription acting on different regulatory mechanisms4-6. Indeed, lncRNAs can act as macro-scaffolds for protein recruitment7-14 and behave as guides and sponges for titrating RNA and proteins, influencing transcription at regulatory regions or triggering transcriptional interfere ...
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