Sethuramasundaram Pitchiaya

The paper identifies widespread readthrough transcription in human cells and shows that depletion of specific factors increases its extent.

This paper identifies LINC00941 as an oncogenic lncRNA regulated by FOSL1 in lung cancer, showing its dual-compartment role in sustaining tumor growth through SAM68 and QKI interactions.

This study shows that HSF1 forms stress-induced condensates with divergent transcriptional outcomes, impacting transcriptional responses during different stress conditions.

This paper introduces CytoTape, a tool for continuous, multiplexed recording of gene regulation dynamics over weeks at single-cell resolution, and demonstrates its use in measuring transcription factor activities.

This study maps the spatiotemporal changes in mouse prostate cellular composition and gene expression after orchiectomy-induced androgen deprivation, identifying new fibroblast subtypes and altered intercellular communication.

This study maps the mouse prostate's cellular organization and identifies key determinants of castration resistance using single-cell and spatial transcriptomics.

This study identifies PCAHIT, a lncRNA linked to poor outcomes in prostate cancer, showing it promotes aggressive phenotypes by affecting steroid biosynthesis and immune response.

The paper tracks RNA localization to processing bodies using single-molecule microscopy and shows that RNA functionality influences their dynamic recruitment to PBs.