Mapping the human genetic architecture of COVID-19: an update

COVID-19 Host Genetics Initiative; Leadership; Gita A. Pathak; Juha M Karjalainen; Christine R. Stevens; Benjamin M. Neale; Mark J. Daly; Andrea Ganna; Writing group; Writing group lead; Shea J. Andrews; Masahiro Kanai; Mattia Cordioli; Analysis group; Manuscript analyses team lead; Manuscript analyses team members: PHEWAS; Renato A Polimanti; Manuscript analyses team members: Mendelian randomization; Nadia V. Harerimana; Manuscript analyses team members: methods development; Matti Pirinen; gene prioritization Manuscript analyses team members: PC projection; Project management group; Project management lead; Rachel G. Liao; Project managment support; Karolina Chwiałkowska; Amy Trankiem; Mary K. Balaconis; Website development

doi:10.1038/s41586-022-04826-7

Genetic & Genomic MedicineNatureAug 3, 2022

Peer-reviewed journal article

Mapping the human genetic architecture of COVID-19: an update

COVID-19 Host Genetics Initiative, Leadership, Gita A. Pathak iD, Juha M Karjalainen iD, Christine R. Stevens iD, Benjamin M. Neale iD, Mark J. Daly iD, Andrea Ganna iD, Writing group, Writing group lead, Shea J. Andrews iD, Masahiro Kanai iD, Mattia Cordioli iD, Analysis group, Manuscript analyses team lead, Manuscript analyses team members: PHEWAS, Renato A Polimanti iD, Manuscript analyses team members: Mendelian randomization, Nadia V. Harerimana iD, Manuscript analyses team members: methods development, Matti Pirinen iD, gene prioritization Manuscript analyses team members: PC projection, Project management group, Project management lead, Rachel G. Liao iD, , David Morrison iD

Abstract

The Coronavirus Disease 2019 (COVID-19) pandemic continues to pose a major public health threat especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity we formed the COVID19 Host Genetics Initiative. Here we present GWAS meta-analysis of up to 125,584 cases and over 2.5 million controls across 60 studies from 25 countries, adding 11 new genome-wide significant loci compared to those previously identified. Genes in novel loci include SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.

PDF DOI