The paper investigates the association between mitochondrial genome abundance and Alzheimer's disease, finding lower abundance correlates with worse neuropathology and cognitive performance.

Alzheimer s & Dementia · Oct 12, 2022Peer-reviewedGenetic & Genomic Medicine

Mapping the human genetic architecture of COVID-19: an update

COVID-19 Host Genetics Initiative, Leadership, Gita A. Pathak, Juha M Karjalainen, Christine R. Stevens, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Writing group, Writing group lead, Shea J. Andrews, Masahiro Kanai, Mattia Cordioli, Analysis group, Manuscript analyses team lead, , David Morrison

This study updates the genetic architecture of COVID-19 by adding 11 new genome-wide significant loci through a large GWAS meta-analysis.

Nature · Aug 3, 2022Peer-reviewedGenetic & Genomic Medicine

Insights into genetic factors contributing to variability in SARS-CoV-2 susceptibility and COVID-19 disease severity

Matteo D’Antonio, Jennifer Nguyen, Timothy D. Arthur, Hiroko Matsui, Agnieszka D’Antonio‐Chronowska, Kelly A. Frazer, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Christine R. Stevens, G. K. Pathak, Shea J. Andrews, Masahiro Kanai, Mattia Cordioli, Juha M Karjalainen, , Rasoul Aliannejad

This study identifies genetic loci associated with SARS-CoV-2 susceptibility and disease severity using GWAS and colocalization, and links them to eQTLs in various tissues.

Cell Reports · Nov 1, 2021Peer-reviewedGenetic & Genomic Medicine

Genetic control of the human brain proteome

Chloe Robins, Yue Liu, Wen Fan, Duc Minh Duong, Jacob Meigs, Nadia V. Harerimana, Ekaterina Sergeevna Gerasimov, Eric B. Dammer, David J. Cutler, Thomas G. Beach, Eric M. Reiman, Philip L. De Jager, David Alan Bennett, James J. Lah, Aliza P. Wingo, , Thomas S. Wingo

The paper identifies pQTLs for brain proteins and finds they differ from eQTLs, suggesting distinct genetic control of mRNA and protein abundance.

The American Journal of Human Genetics · Feb 10, 2021Peer-reviewedGenetics

Regulation of meiotic progression by Sertoli-cell androgen signaling

Hailey Larose, Travis Kent, Qianyi Ma, Adrienne Niederriter Shami, Nadia V. Harerimana, Jun Z. Li, Saher Sue Hammoud, Mary Ann Handel

The paper shows that Sertoli-cell androgen signaling is not required for meiotic prophase initiation but is essential for meiotic division phase competence in spermatocytes.

Molecular Biology of the Cell · Oct 7, 2020Peer-reviewedGenetics

Cerebral atherosclerosis contributes to Alzheimer’s dementia independently of its hallmark amyloid and tau pathologies

Aliza P. Wingo, Wen Fan, Duc Minh Duong, Ekaterina Sergeevna Gerasimov, Eric B. Dammer, Yue Liu, Nadia V. Harerimana, Bartholomew White, Madhav Thambisetty, Juan Carlos Troncoso, Namhee Kim, Julie A. Schneider, Ihab M. Hajjar, James J. Lah, David Alan Bennett, , Thomas S. Wingo

This study identifies 114 proteins and 5 modules linked to cerebral atherosclerosis in the brain, with 23 proteins and 2 modules also associated with Alzheimer’s dementia, highlighting shared mechanisms involving synaptic signaling and myelination.

Nature Neuroscience · May 18, 2020Peer-reviewedNeuroscience