mSphereGeneticsPeer-reviewed journal article
Repression of YdaS Toxin is Mediated by Transcriptional Repressor RacR in the cryptic rac prophage of Escherichia coli K12
Revathy KrishnamurthiiD, Swagatha GhoshiD, Supriya KhedkariD, Aswin Sai Narain SeshasayeeiD
Abstract
AbstractHorizontal gene transfer is a major driving force behind the genomic diversity seen in prokaryotes. The rac prophage in E.coli K12 encodes a putative transcription factor RacR, whose deletion is lethal. We have shown that the essentiality of racR in E.coli K12 is attributed to its role in transcriptionally repressing a toxin gene called ydaS, which is coded adjacent and divergently to racR.
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