R. Loris

Structural insights into Charcot-Marie-Tooth disease-linked mutations in human GDAP1

This study investigates the structural and biochemical effects of CMT-linked GDAP1 mutations, finding reduced thermal stability and disrupted interaction networks that may impair neuronal function.

High-affinity nanobodies as tools for structural and functional studies on mammalian Arc

This study produces and characterizes high-affinity anti-Arc nanobodies, revealing structural dynamics of Arc CTD and its role in oligomerization and capsid formation.

Vibrio cholerae ParE2 toxin modulates its operon transcription by stabilization of an antitoxin DNA ruler

This study investigates how ParE2 toxin modulates its operon transcription by stabilizing the antitoxin DNA ruler through protein-DNA interactions and structural analysis.

Alternative dimerization is required for activity and inhibition of the HEPN ribonuclease RnlA

This study identifies the structural basis of RnlA activity and inhibition through dimerization and residue-specific interactions.

Entropic pressure controls oligomerization of Vibrio cholerae ParD2 antitoxin

This study shows that the intrinsically disordered C-terminal domain of VcParD2 restricts its oligomerization to stable 10-mer or 12-mer structures due to entropic pressure.

Arabidopsis Casein Kinase 2 triggers Stem Cell Exhaustion under Al Toxicity and Phosphate Deficiency Through activation of the DNA Damage Response pathway

The paper identifies CK2 and DNA damage response regulators as key factors in controlling Arabidopsis root growth under Al toxicity and phosphate limitation.

Structure of the complete dimeric human GDAP1 core domain provides insights into ligand binding and clustering of disease mutations

The paper determines the crystal structure of the human GDAP1 core domain, identifies a fatty acid ligand, and reveals structural insights into disease-related mutations and oligomerization.

Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase

The paper determines the crystal structure of mouse CSAD, identifies substrate specificity determinants, and shows open/close motions in solution.

The TPLATE subunit is essential for structural assembly of the endocytic TSET complex

The paper determines the structural architecture of the plant TSET complex and identifies key interactions essential for its assembly and function in endocytosis.

Molecular determinants of Arc oligomerization and formation of virus-like capsids

This paper identifies a 28-amino-acid region in Arc critical for oligomerization and virus-like capsid formation, showing that exogenous RNA enhances assembly.