bioRxivImmunologyPreprint
Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity
A. Moreno, K. Manning, M. I. Azeem, A. K. Nooka, M. Ellis, R. J. Manalo, J. M. Switchenko, B. Wali, J. L. Kaufman, C. C. Hofmeister, N. S. Joseph, S. Lonial, K. M. Dhodapkar, M. V. Dhodapkar, M. S. Suthar
Abstract
We characterized virus-neutralization and spike-binding antibody profiles in myeloma patients following monovalent or bivalent-SARS-CoV-2 booster vaccination. Vaccination improves the breadth of binding antibodies but not neutralization activity against current variants. Hybrid immunity and immune imprinting impact vaccine-elicited immunity.
- organism: human
- assay: proteomics
- research focus: host-pathogen & immune response
- approach: experimental assay
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