Author

E. C. Wall

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2

Frequent Co-Authors

J. S. Brown· 3 shared R. J. Wilkinson· 3 shared A. Hobbs· 2 shared B. Williams· 2 shared C. Swanton· 2 shared C. Venturini· 2 shared D. G. Lalloo· 2 shared D. L. Bauer· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersImmunology

J. S. Brown

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The Streptococcus pneumoniae transcriptome in patient cerebrospinal fluid identifies novel virulence factors required for meningitis

E. C. Wall, J.-A. Guerra-Assuncao, M. Yang, R. Konig, T. Audshasai, A. Proust, R. Aprianto, E. Ramos-Sevillano, G. Ercoli, N. Bordin, V. S. Agostinho-Terra, J.-W. Veening, D. G. Lalloo, B. W. Wren, R. J. Wilkinson, , J. S. Brown

The paper uses RNA sequencing of cerebrospinal fluid from meningitis patients to identify S. pneumoniae virulence factors, finding two genes linked to increased mortality and reduced infection persistence.

bioRxiv · Apr 30, 2024 · PreprintMicrobiology

Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1

G. Dowgier, A. Hobbs, D. Greenwood, M. Shawe-Taylor, P. Stevenson-Leggett, J. Bazire, R. Penn, R. Harvey, V. Libri, G. Kassiotis, S. Gamblin, N. S. Lewis, B. Williams, C. Swanton, S. Gandhi, , M. Y. Wu

The paper evaluates neutralising antibody titres against SARS-CoV-2 variant JN.1 using live-virus microneutralisation assays in vaccinated individuals, finding higher titres in monovalent vaccine recipients.

bioRxiv · Apr 17, 2024 · PreprintMicrobiology

Dichotomy of neutralizing antibody, B cell and T cell responses to SARS-CoV-2 vaccination and protection in healthy adults

E. J. Carr, H. Townsley, M. Y. Wu, K. A. Wilkinson, P. S. Hobson, D. Levi, S. Namjou, H. V. Mears, A. Hobbs, M. Ragno, L. S. Herman, R. Harvey, C. Bailey, A. S. Fowler, E. Hatipoglu, , E. C. Wall

The paper identifies four patterns of SARS-CoV-2 vaccine responses, including broad and narrow responders, and links broad responder traits to longer infection-free time after vaccination.

bioRxiv · May 24, 2023 · PreprintImmunology

O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern

E. Gonzalez-Rodriguez, M. Zol-Hanlon, G. Bineva-Todd, A. Marchesi, M. Skehel, K. Mahoney, C. Roustan, A. Borg, L. Di Vagno, S. Kjaer, A. G. Wrobel, D. J. Benton, P. Nawrath, S. L. Flitsch, D. Joshi, , B. Schumann

This paper shows that O-linked sialoglycans affect SARS-CoV-2 spike proteolysis by furin and TMPRSS2, and may drive mutations in variants of concern.

bioRxiv · Sep 15, 2022Cell Biology

Both the inflammatory response and clinical outcome differ markedly between adults with pneumococcal and meningococcal meningitis in a high HIV-1 prevalent setting in sub-Saharan Africa

E. C. Wall, J. A. Guerra-Assuncao, B. Denis, M. Scarborough, K. Ajdukiewicz, K. Cartwright, M. Mukaka, V. S. Mlozowa, C. Venturini, T. J. Allain, D. G. Lalloo, J. S. Brown, S. B. Gordon, R. S. Heyderman

This study compares inflammatory responses and clinical outcomes between pneumococcal and meningococcal meningitis in HIV-high prevalence settings, finding worse outcomes in pneumococcal cases.

bioRxiv · Feb 3, 2019 · PreprintImmunology

Cerebrospinal fluid transcriptional analyses reveals upregulation of IL-17, Type 1 interferon transcriptional pathways and neutrophil persistence genes associated with increased mortality from pneumococcal meningitis in adults

E. C. Wall, J. A. Guerra-Assuncao, G. Pollara, C. Venturini, V. Mlowzowa, T. Allain, D. Lalloo, M. Noursadeghi, J. S. Brown, R. Heyderman

The paper identifies CSF gene expression patterns associated with increased mortality in pneumococcal meningitis, highlighting IL-17, Type 1 interferon, and neutrophil persistence pathways.

bioRxiv · Dec 7, 2018 · PreprintImmunology