Effect of Mangiferin Isolated from Hedysarum neglectum L. Root Culture on Fat Accumulation in Experiments In Vivo

Abstract

Plant polyphenols possess diverse medicinal and therapeutic properties. For instance, they can prevent such age-related diseases as stroke, heart attack, type II diabetes, and their various pathological complications. Mangiferin is a polyphenolic compound with a C-glycosylxanthone structure. This biologically active substance is known for its antioxidant, anti-inflammatory, antimicrobial, antidiabetic, and immunomodulatory properties. This research features mangiferin isolated from Hedysarum neglectum L. root culture and its effect on fat accumulation in Caenorhabditis elegans N2 Bristol. A set of experiments in vivo proved that mangiferin was able to inhibit fat accumulation in the model organism. The optimal concentration was determined as 50 m: it provided 44.5% fluorescence.