D. A. Howatt

Renal Proximal Tubule Cell-specific Megalin Deletion Does Not Affect Atherosclerosis But Induces Tubulointerstitial Nephritis in Mice Fed Western Diet

This study shows that deleting megalin in renal proximal tubule cells does not reduce atherosclerosis but causes tubulointerstitial nephritis in male mice fed a Western diet.

Beta-aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Young Mice

This study shows that BAPN induces distinct aortic pathologies in the ascending and descending thoracic aortas of young mice, with different structural and cellular changes in each region.

Effects of Endogenous Angiotensin II on Abdominal Aortic Aneurysms and Atherosclerosis in Angiotensin II-infused Mice

This study examines how endogenous AngII levels change with exogenous AngII infusion and their impact on AAA and atherosclerosis in mice.

Inhibition of Angiotensin II Dependent AT1a Receptor Stimulation Attenuates Thoracic Aortic Pathology in Fibrillin-1C1041G/+ Mice

This study shows that inhibiting the AngII-AT1aR axis reduces aortic pathology in male Fbn1C1041G/+ mice, suggesting ligand-dependent AT1aR stimulation contributes to TAA progression.

Bitter Melon (Momordica Charantia) Supplementation Has no Effect on Hypercholesterolemia and Atherosclerosis in Mice

This study finds that bitter melon supplementation does not affect hypercholesterolemia or atherosclerosis in LDL receptor deficient mice.

Ultrasound Monitoring of Descending Aortic Aneurysms and Dissections in Mice

This study introduces a para-spinal dorsal ultrasound approach to visualize descending aortic regions in mice, overcoming limitations of standard methods.

Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending Aortopathies

This study shows SHF-derived cells contribute to AngII-induced ascending aortic pathologies through LRP1 and TGF-β signaling, increasing PAI1 expression.

Hypercholesterolemia Accelerates Both the Initiation and Progression of Angiotensin II-induced Abdominal Aortic Aneurysms

This study shows hypercholesterolemia speeds up both the start and growth of angiotensin II-induced abdominal aortic aneurysms in mice.

The Two Amino Acids Proximate to the Renin Cleavage Site of Human Angiotensinogen Do Not Affect Angiotensin II-mediated Functions in Mice

This study shows that replacing amino acids 11 and 12 in mouse angiotensinogen with human counterparts does not affect renin cleavage or angiotensin II-mediated functions in mice.