Author

V. L. Li

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Physiology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:metabolomics· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

J. Z. Long· 6 shared W. Wei· 4 shared A. L. Wiggenhorn· 3 shared X. Lyu· 3 shared J. T. Tanzo· 2 shared R. E. Gerszten· 2 shared S. Deng· 2 shared S. M. Terrell· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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6 shared papersBiochemistry

J. Z. Long

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Author profile →

6 papers

Recent·Most cited

SLC17 transporters mediate renal excretion of Lac-Phe in mice and humans

V. L. Li, S. Xiao, P. Schlosser, N. Scherer, A. L. Wiggenhorn, J. Spaas, A. S.-H. Tung, E. D. Karoly, A. Kottgen, J. Z. Long

This study identifies SLC17A1 and SLC17A3 as key transporters for Lac-Phe excretion in urine, showing genetic and functional associations in mice and humans.

bioRxiv · Apr 18, 2024 · PreprintBiochemistry

Lac-Phe mediates the anti-obesity effect of metformin

S. Xiao, V. L. Li, X. Lyu, X. Chen, W. Wei, F. Abbasi, J. Knowles, S. Deng, G. Tiwari, X. Shi, S. Deng, L. Farrell, Z.-Z. Chen, K. Taylor, X. Guo, , J. Z. Long

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

bioRxiv · Nov 2, 2023 · PreprintPhysiology

A class of secreted mammalian peptides with potential to expand cell-cell communication

A. L. Wiggenhorn, H. Z. Abuzaid, L. Coassolo, V. L. Li, J. T. Tanzo, W. Wei, X. Lyu, K. J. Svensson, J. Z. Long

The paper identifies a new class of secreted mammalian peptides, capped peptides, which may regulate cell-cell communication through post-translational modifications.

bioRxiv · Jun 2, 2023Physiology

CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels

J. T. Tanzo, V. L. Li, A. L. Wiggenhorn, M. D. M. Garzon, W. Wei, X. Lyu, W. Dong, U. Tahir, Z.-Z. Chen, D. E. Cruz, S. Deng, X. Shi, S. Zheng, Y. Guo, M. Sims, , M. D. Benson

The paper identifies CYP4F2 as a human-specific genetic determinant of plasma N-acyl amino acid levels and shows its role in metabolic diversification.

bioRxiv · Mar 9, 2023Biochemistry

A screen of covalent inhibitors in Mycobacterium tuberculosis identifies serine hydrolases involved in lipid metabolism as potential therapeutic targets

B. M. Babin, L. J. Keller, Y. Pinto, V. L. Li, A. Eneim, S. E. Vance, S. M. Terrell, A. S. Bhatt, J. Z. Long, M. Bogyo

bioRxiv · Jun 7, 2021 · PreprintMicrobiology

Cell type-selective secretome profiling in vivo

W. Wei, N. M. Riley, A. C. Yang, J. T. Kim, S. M. Terrell, V. L. Li, M. Garcia-Contreras, C. R. Bertozzi, J. Z. Long

The paper introduces a method to profile cell-type-specific secretomes in vivo and identifies novel secreted proteins and dynamic changes in hepatocyte secretomes.

bioRxiv · Sep 18, 2020Biochemistry