Epilepsy research and treatment

Fast-ripples are emergent properties of neuronal networks

Most fast-ripples (250-500 Hz) in rat and human recordings are consistent with chance clustering of action potentials; in awake patients, distinct events make up an estimated 37.5% of detections.

H3K27 trimethylation maintains baseline network excitability in epilepsy

In mice 4 days after kainate-induced status epilepticus, H3K27me3 gains coincide with repression of excitability genes; EZH2 inhibition with UNC1999 lowers seizure threshold acutely and increases chronic seizure frequency.

Synaptic Ultrastructural Alterations in Human Focal Cortical Dysplasia: Insights from Volume Electron Microscopy

Volume EM of one focal cortical dysplasia type I patient shows fewer somatic inhibitory and dendritic excitatory synapses, oversized vesicle-rich excitatory synapses, and thicker myelin.