Author

Barry A. Schoenike

University of Wisconsin–Madison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Avtar RoopraiD· 5 shared Jennifer L. KoehleriD· 4 shared Jose Ezekiel Clemente EspinaiD· 4 shared Olivia R. HoffmaniD· 4 shared Jamie L. MaguireiD· 2 shared Quinn R. Harvey· 2 shared Raymond J DingledineiD· 2 shared Anna M. PattersoniD· 1 shared

Activity by Year

2019-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersNeuroscience

Avtar RoopraORCID

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5 papers

Recent·Most cited

Tofacitinib overrides first-line drug resistance in a pre-clinical model of epilepsy

Jennifer L. Koehler, Olivia R. Hoffman, Quinn R. Harvey, Barry A. Schoenike, Jose Ezekiel Clemente Espina, Avtar Roopra

This study shows that tofacitinib, a JAK inhibitor, reduces seizures and improves cognition in a mouse model of drug-resistant epilepsy when used as an add-on therapy to carbamazepine.

bioRxiv · Oct 5, 2026 · PreprintNeuroscience

A network approach with motion sequencing reveals hidden patterns of repetitive behavior in a pre-clinical model of epilepsy

Jennifer L. Koehler, Quinn R. Harvey, Olivia R. Hoffman, Jose Ezekiel Clemente Espina, Barry A. Schoenike, Cameron P.E. Jones, Grant L. Weiss, Jamie L. Maguire, Avtar Roopra

This study uses Motion Sequencing combined with a novel analysis pipeline to identify repetitive behaviors in epileptic mice and shows that carbamazepine partially rescues these behaviors.

Epilepsy & Behavior · Aug 1, 2026Peer-reviewedNeuroscience

H3K27 trimethylation maintains baseline network excitability in epilepsy

Jose Ezekiel Clemente Espina, Olivia R. Hoffman, Jennifer L. Koehler, Barry A. Schoenike, Avtar Roopra

In mice 4 days after kainate-induced status epilepticus, H3K27me3 gains coincide with repression of excitability genes; EZH2 inhibition with UNC1999 lowers seizure threshold acutely and increases chronic seizure frequency.

bioRxiv · Jul 30, 2026 · PreprintNeuroscience✦ In-depth digest

Disease modification upon brief exposure to tofacitinib during chronic epilepsy.

Olivia R. Hoffman, Jennifer L. Koehler, Jose Ezekiel Clemente Espina, Anna M. Patterson, Emily S. Gohar, Emanuel M. Coleman, Barry A. Schoenike, Claudia Espinosa‐García, Felipe Paredes, Nicholas H. Varvel, Raymond J Dingledine, Jamie L. Maguire, Avtar Roopra

The paper shows that brief tofacitinib treatment suppresses seizures and reverses cognitive deficits in chronic epilepsy by targeting a resurgent JAK/STAT pathway activation.

bioRxiv · Aug 7, 2023 · PreprintNeuroscience

A Systems Approach Identifies Enhancer of Zeste Homolog 2 (EZH2) as a Protective Factor in Epilepsy

Nadia Khan, Barry A. Schoenike, Trina Basu, Heidi L. Grabenstatter, Genesis Rodriguez, Caleb Sindic, Margaret Johnson, Eli P. Wallace, Rama K. Maganti, Raymond J Dingledine, Avtar Roopra

This paper identifies EZH2 as a protective factor in epilepsy using a systems approach to analyze transcriptomic data from rodent and human samples.

PLoS ONE · Dec 31, 2019Peer-reviewedNeuroscience