Matthew C. Walker

Human Hippocampal Theta-Gamma Phase-Amplitude Coupling Signals the Distance to Remembered Goals

The paper investigates theta-gamma phase-amplitude coupling in human hippocampal LFP during navigation, finding it correlates with proximity to remembered goals.

Fast-ripples are emergent properties of neuronal networks

Most fast-ripples (250-500 Hz) in rat and human recordings are consistent with chance clustering of action potentials; in awake patients, distinct events make up an estimated 37.5% of detections.

Impaired Associative Memory, Inference, and Theta Dynamics in Postictal Psychosis of Epilepsy

This study finds impaired associative memory and inference in postictal psychosis, linked to disrupted theta band activity, suggesting shared neural mechanisms with schizophrenia.

Neural Extracellular Matrix Remodeling Signatures in Genetic and Acquired Mouse Models of Epilepsy

The paper investigates ECM remodeling in different epilepsy models and identifies ECM components that predict seizure properties.

Volume-transmitted GABA waves pace epileptiform rhythms in the hippocampal network

The paper shows that volume-transmitted GABA waves drive epileptiform rhythms in hippocampal networks by elevating tonic GABAA receptor conductance across multiple cells.

Magnetic Field Mapping and Correction for Moving OP-MEG

This paper models and corrects magnetic field variations in moving OP-MEG data to reduce movement artefacts.

Genetic dissection of Down syndrome-associated alterations in APP/amyloid-β biology using mouse models

This study identifies non-APP chromosome 21 genes that influence amyloid-β biology in Down syndrome mouse models, independent of APP copy number.

LGI1 downregulation increases neuronal circuit excitability

This study shows that reducing LGI1 levels increases neuronal excitability and synaptic plasticity, potentially contributing to epilepsy and limbic encephalitis.

Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome

The paper identifies distinct hippocampal and prefrontal cortex circuit dysfunctions in DS mouse models linked to specific regions of human chromosome 21.

Theta power and theta-gamma coupling support spatial memory retrieval

The paper shows that increased theta power and theta-gamma coupling during spatial memory retrieval in humans correlates with better task performance.

Epilepsy gene therapy using non-integrating lentiviral delivery of an engineered potassium channel gene

This paper develops a non-integrating lentiviral gene therapy for refractory focal epilepsy, showing reduced seizure frequency in a rat model.

Semiology, clustering, periodicity and natural history of seizures in an experimental visual cortical epilepsy model

This paper characterizes a rat model of focal neocortical epilepsy induced by tetanus toxin injection, showing seizure clustering, circadian variation, and predictive seizure counts.