Antifungal resistance and susceptibility

Population genomics of Candida albicans reveals genetic footprints that allow the prediction of antifungal resistance

This study uses population genomics and machine learning to identify genetic markers predictive of antifungal resistance in Candida albicans, highlighting the need for expanded resistance catalogues.

Pulmonary colonization of Candida albicans drives breast cancer lung metastasis via candidalysin

This study shows that Candida albicans colonization in the lungs promotes breast cancer metastasis by activating mast cells and creating an immunosuppressive environment.

Host brain infection induces RNAi epimutation in Mucor circinelloides and enhances blood-brain barrier invasion

The paper shows brain infection induces RNAi epimutations in Mucor circinelloides that enhance blood-brain barrier invasion.

Structural basis of caspofungin inhibition of Nakaseomyces glabratus Fks1

This study presents the structural analysis of NgFks1 in apo and caspofungin-bound states, revealing species-specific differences in inhibition and resistance mechanisms.

Macrophage PHOX Restricts Aspergillus fumigatus Germination and Hyphal Development Through ROS-Dependent Immunity

This study shows macrophage-derived ROS restricts A. fumigatus germination and hyphal growth, while fungal melanin limits ROS activity, promoting immune evasion.