Darpan Raghav

This study presents the structural analysis of NgFks1 in apo and caspofungin-bound states, revealing species-specific differences in inhibition and resistance mechanisms.

This study shows that reducing neuronal mitochondrial calcium uptake in AD mouse models decreases pathology, synaptic dysfunction, and cognitive decline.

The paper determines the cryo-EM structure of Ycf1 bound to oxidized glutathione and identifies a 'flex-pocket' mechanism for substrate binding and specificity.