Author

Ziyan Xu

Duke UniversityORCID 0009-0001-7055-9788Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:fungi (other)· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Carlos Pérez ArquesiD· 4 shared Joseph HeitmaniD· 4 shared María Isabel Navarro-MendozaiD· 4 shared Grit WaltheriD· 2 shared E. Ashley MosemaniD· 1 shared Emma Cao· 1 shared Josie E. ParkeriD· 1 shared Lysett WagneriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersGenetics

Carlos Pérez ArquesORCID

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4 papers

Recent·Most cited

GeneticsbioRxivPreprintOct 28, 2026

A single meiotic product dominates inheritance in Mucor circinelloides

Carlos Pérez Arques, María Isabel Navarro-Mendoza, Ziyan Xu…·Joseph Heitman

The paper shows that meiosis in Mucor circinelloides produces genetically uniform progeny from a single meiotic product, unlike conventional meiosis.

DOI 10.64898/2026.10.23.761428

fungi (other)whole-genome sequencing

𝕏 PostBluesky

GeneticsbioRxivPreprintOct 25, 2026

Host brain infection induces RNAi epimutation in Mucor circinelloides and enhances blood-brain barrier invasion

María Isabel Navarro-Mendoza, Carlos Pérez Arques, Yeseul Choi…·Joseph Heitman

The paper shows brain infection induces RNAi epimutations in Mucor circinelloides that enhance blood-brain barrier invasion.

DOI 10.64898/2026.10.23.761329

𝕏 PostBluesky

MicrobiologyNature CommunicationsPeer-reviewedAug 7, 2025

RNAi epimutations conferring antifungal drug resistance are inheritable

Carlos Pérez Arques, María Isabel Navarro-Mendoza, Ziyan Xu…·Joseph Heitman

This study shows RNAi epimutations conferring antifungal drug resistance are transgenerationally inherited in Mucor circinelloides, independent of DNA sequence and other epigenetic factors.

19 citationstop 3%

fungi (other)ChIP-seq

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MicrobiologymBioPeer-reviewedJul 9, 2024

Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the Mucor species complex

María Isabel Navarro-Mendoza, Carlos Pérez Arques, Josie E. Parker…·Joseph Heitman

This study identifies Erg3 and Erg6a as key enzymes in the ergosterol biosynthetic pathway of Mucor circinelloides, showing their roles in antifungal drug resistance and virulence.

21 citationstop 2%

fungi (other)experimental assay

𝕏 PostBluesky